Q. What can be the reason for raised liver enzymes during fever?

Answered by
Dr. Sadaf Mustafa
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Nov 12, 2016 and last reviewed on: Jun 14, 2019

Hi doctor,

The issue is from 39 years ago. When I was 13 years old, I was considered for the possibility of poisoning. I was admitted to hospital for 8 days and the diagnoses were cervical adenitis and viral syndrome. I had a fever of 103 degrees for several days before going to hospital. My throat culture grew Strep. On admission to hospital, CBC showed WBC 12,900 (normal range), Hb 13.2, Hct 38.7, 36 lymphocytes, 9 monocytes, 7 eosinophils and the platelets were adequate. The almond size lymph node on the left cervical chain and the right side lymph was golf ball size. The neck was supple, no rigidity and some restriction of movement. There is no mass or thyroid palpable. The rest of the physical examination is within normal limits. Total bilirubin 0.4, ALT or SGPT was 714 initially and on discharge it was 215. SGOT or AST was 426 initially and 202 on discharge. LDH was 297 and then 217 on the day of discharge and albumin 3.8.  I am trying to figure out why my liver enzymes were so high initially and 8 days later they came down. I was treated with Keflex IV antibiotic, which cured the infection. Mono spot was negative. Urine and blood cultures are negative. From what I read, the liver cause could be toxic. But, at the of 13, I neither drink, nor had hepatitis.

Dr. Sadaf Mustafa

General Medicine Internal Medicine


Welcome to icliniq.com.

  • As far as I know, Strep throat should not give you transaminitis unless you had multi organ system dysfunction, which would also include worsening of renal function.
  • The other possibility could be using medications like Acetaminophen to reduce the fever before admission.
  • Some viral syndromes can also cause (viral infection without any cause) elevated liver function test, especially if the Strep was a secondary infection, which happens very often.
  • What about now? Do you have normal liver function test?

Revert back with the answer to the above questions to an internal medicine physician online --> https://www.icliniq.com/ask-a-doctor-online/internal-medicine-physician

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Thank you doctor,

I do not think I had Acetaminophen, but may be Aspirin. I also think the viral syndrome was just something that they could not pinpoint, which I guess is normal for that diagnosis. I have normal liver functions now. I am 52 years old. I have had my gall bladder removed a few years ago. I was wondering about poisoning, as my mother was always somewhat psychologically unstable and violent at times. I thought maybe there was a possibility that she fed me something or I drank something that she may have poisoned.

Dr. Sadaf Mustafa

General Medicine Internal Medicine


Welcome back to icliniq.com.

Thank you for the updates.

  • It is unlikely to be poisoning. We are wishing you the best of health.

For further information consult an internal medicine physician online --> https://www.icliniq.com/ask-a-doctor-online/internal-medicine-physician

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