Why my joint pain is worsening despite taking Hydroxychloroquine?

Question

Hello doctor,

I am 47 years old and have been living with rheumatoid arthritis for almost six years now. Recently, I have been noticing more severe pain and swelling in my joints, particularly in my hands and knees. The stiffness in the mornings is almost unbearable, and I am finding it difficult to get out of bed and start my day. I have been taking hydroxychloroquine for the past year, but it does not seem to be working as effectively as it used to. My RF level is 115 IU/mL, and my CRP level is 26 mg/L, indicating that inflammation is still high. I am really worried that my condition is progressing. Should I consider biologic treatments or another approach? What do you think would be the most effective way to manage this at this stage?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and understood your concern.

Given your condition, it may be time to consider biologic medications, especially since Hydroxychloroquine is no longer effectively controlling your condition. Biologic medications target specific parts of the immune system and can reduce inflammation more effectively than traditional disease-modifying antirheumatic drugs (DMARDs) like Hydroxychloroquine. Drugs such as tumor necrosis factor (TNF) inhibitors or interleukin-6 (IL-6) inhibitors have shown promising results in controlling symptoms and preventing joint damage in rheumatoid arthritis.

I suggest you discuss this option with your rheumatologist, who can guide you based on your current condition, treatment response, and any potential risks.

Early intervention with biologics can help slow disease progression. I suggest you consider an anti-inflammatory diet, which includes foods like almonds, salmon, and omega-3 fatty acids.

I hope this has helped you.

Kindly follow up if you have more doubts.

Thank you.