Sex Hormone-binding Globulin (SHBG) is a protein synthesized by the liver which readily attaches to the sex hormones found in both men and women. These include Testosterone and Dihydrotestosterone found in males and Estradiol found in females. SHBG limits the number of hormones presented to the body. Although it binds to all three hormones, this test is used to detect the testosterone used by the body.
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