What can be done to treat non-radiographic spondylarthritis?

Question

Hello doctor,

I am a 37-year-old female, and I have been experiencing persistent pain and stiffness in my spine and lower back. Occasionally, I also feel similar symptoms in my knees and heels, along with gastrointestinal upset. My doctor suspects that I may have non-radiographic spondylarthritis. Could you please explain what this condition is? Is it curable or not? What causes it, and how can it be diagnosed? What are the management options for this condition?

Please advise.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Non-radiographic axial spondyloarthritis (nr-AxSpA) is an inflammatory arthritis primarily affecting the spine. It is part of the broader group of diseases known as spondyloarthritis, where inflammation in the spine is a common feature. Although the exact cause is unknown, nr-AxSpA is believed to be autoimmune in origin.

Diagnosis: The diagnosis of nr-AxSpA can be challenging as it does not show clear abnormalities on X-rays. MRI findings might reveal an inflammatory response in the sacroiliac joints, and genetic testing for HLA-B27 can be performed. However, the condition is often diagnosed based on clinical symptoms and by ruling out other potential causes. There may also be a genetic predisposition, meaning that having a family history of the disease could increase the likelihood of developing it.

Treatment: While nr-AxSpA cannot be cured, its symptoms can be managed effectively. The treatment strategy typically begins with symptom control, and if the response is insufficient, the following options may be considered:

1. Non-biologic disease-modifying antirheumatic drugs (DMARDs): To help manage inflammation and prevent joint damage.

2. Biologics (medications derived from living organisms used to target specific molecules in autoimmune diseases and cancers): If non-biologic medications do not provide adequate relief, biologic therapies may be recommended.

I suggest consulting your specialist doctor, discussing the treatment options with them, and following their guidance for the appropriate management plan.

I hope I have answered your query.

Thank you.