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I am a transgender female. Are there any markers in one's blood that indicate their sex?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I am a 65 year old transgender female, and I have been on hormone therapy for the past two years. I have had an orchidectomy but not gender reassignment surgery. I recently donated blood, and on the questionnaire, it asked for my biological sex. The person there said that because I was born male, my biological sex would always be male. Are there any markers in one's blood that indicate their sex?

Hi,

Welcome to icliniq.com.

  • Every cell in your body has DNA (deoxyribonucleic acid) that defines the genetic makeup. A male is XY and a female is XX. Other than red blood cells, which does not have DNA, rest every cell of the body has DNA.
  • The blood is a mixture of all different kinds of proteins and cells, and the genetic makeup can be determined by sampling it.

Hope I have answered your question. Any further comments and questions are welcome. Regards.

For further queries consult an internal medicine physician online.

Medically reviewed byiCliniq medical review team

Published At May 29, 2017
Reviewed AtApril 13, 2025

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