I am 61 with T2D. Are there new treatments to manage it?

Question

Hello doctor,

I am 61, and my type 2 diabetes has become completely unmanageable over the past 18 months despite being on maximum doses of four different medications. My blood glucose readings are consistently above 400 mg/dL and frequently spike over 550 mg/dL after meals, even when I follow the diabetic diet plan exactly as prescribed. I am on Metformin, long-acting insulin, a GLP-1 agonist, and an SGLT2 inhibitor, but my HbA1C is 13.2, which I know is dangerously high and potentially fatal.

The constant severe hyperglycemia makes me feel exhausted, incredibly thirsty, and I am urinating every 20 minutes throughout the day and night, disrupting all normal activities. I am already developing serious complications, including significant vision impairment that makes driving unsafe, severe neuropathy with burning pain in both feet, and slow-healing wounds that terrify me about amputations. My endocrinologist keeps increasing medication doses, but the side effects are becoming intolerable, including severe gastrointestinal problems and continued weight gain despite eating restrictions.

I am scared about going blind, losing limbs, or dying from diabetic ketoacidosis like my father did at age 63 from uncontrolled diabetes. Work is becoming impossible because I feel mentally confused and physically weak most days, and I may need to file for disability benefits. Are there any newer diabetes technologies, like advanced insulin pump systems or experimental treatments, that might help someone with such severe insulin resistance?

I am willing to try anything because this disease is rapidly destroying my body, and I feel like I am dying.

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

Thanks for sharing this so clearly.

Blood sugars persistently higher than 400 mg/dL despite maximum therapy, with HbA1C more than 13%, symptoms, and progressive complications, is a life-threatening medical emergency. You should seek urgent medical care (such as an emergency room visit or hospital admission) rather than waiting for outpatient adjustments.

Immediate priorities that you need to follow are:

Hospital admission: In cases like yours, we typically admit patients for IV (intravenous) insulin infusion (much more controlled than injections at home), careful rehydration (since you are urinating constantly and at risk for dehydration and electrolyte loss), and monitoring and stabilizing until sugars are brought into a safe range.
Transition to intensive insulin therapy: Once stable, you may need a full basal–bolus regimen with meal-time rapid insulin, carefully titrated. Sometimes, U-500 concentrated insulin is used in patients with very severe insulin resistance. Metformin and GLP-1 (glucagon-like peptide-1) can often still be kept for weight and cardiovascular protection (if tolerated).
Screening for other causes: When diabetes becomes “suddenly unmanageable” despite maximal therapy, physicians often look for secondary causes (Cushing’s, steroid medications, infections, and pancreatic issues) and latent autoimmune diabetes in adults (LADA) or “burnt-out” type 2 transitioning toward an insulin-dependent state.

Here are some advanced and newer options, which are considered after stabilization:

Insulin pumps with CGM (continuous glucose monitoring) integration (hybrid closed-loop systems): Modern pumps (Tandem Control-IQ, Medtronic 780G, Omnipod 5), continuous glucose monitors (Dexcom, Libre, Guardian) can automatically adjust insulin delivery. They work best once insulin requirements are better understood, but even in resistant type 2, pumps can be life-changing.
Metabolic surgery: If BMI (body mass index) is high, gastric bypass or sleeve gastrectomy can sometimes lead to complete remission of type 2 diabetes, even in patients with a very long duration.
Emerging therapies: Tirzepatide (a dual GLP-1/GIP (glucose-dependent insulinotropic polypeptide receptor) agonist) has a more substantial effect than older GLP-1s, often lowering A1C by more than 2 to 3%.
Anti-obesity medications (Semaglutide, Retatrutide in trial): This can dramatically improve insulin sensitivity.

You are right to think about disability, but you can still avoid the situation. With intensive inpatient insulin management, sugars can often be brought down to safe ranges within days. The exhaustion, confusion, and pain you describe will improve as your sugar control improves. Protecting your eyes, nerves, and kidneys depends on good glycemic control.

Please go to the emergency department today or call your doctor and insist on hospital admission for stabilization with IV insulin. This is not something that can be safely managed with more pills or small dose changes at home.

I hope my explanation has been clear and sufficient for you, and I am always available if you have any questions.

Thank you.