Patient's Query
Hello doctor,
I am a 25-year-old female, diagnosed with ulcerative colitis two years ago. I get frequent flare-ups with bloody diarrhea, abdominal cramps, and weight loss. My last colonoscopy showed moderate inflammation. I am on Mesalamine, but flares still happen.
The doctor mentioned biologics as the next option, but I am scared of side effects. I am looking for your suggestions on the following:
Can food trigger flares?
Is it possible to go into permanent remission?
Also, does ulcerative colitis increase the risk of colon cancer in the long term?
Kindly suggest.
Hello,
Welcome to icliniq.com.
I understand your concern.
With moderate inflammation and frequent flares despite Mesalamine, you are not in stable remission. First, make sure that Mesalamine is optimized (full oral dose plus rectal mesalamine enema or suppository if disease is left-sided or rectal) and rule out infection (C. difficile (Clostridium difficile)).
If you need repeated steroids, have bleeding, weight loss, or persistently high inflammatory markers, stepping up therapy is appropriate.
Biologics (anti-TNF (anti-tumor necrosis factor) agents such as Vedolizumab, Ustekinumab, and others) are used to achieve “deep remission” and reduce hospitalizations or surgery.
Side effects are mainly infections (TB (tuberculosis) and hepatitis screening, and keeping vaccines up to date are important) and rare malignancy signals; for most patients, uncontrolled UC (ulcerative colitis) and repeated steroid exposure are riskier.
Food does not usually cause inflammation, but it can trigger symptoms.
During flares, choose low-residue or low-fat foods, stay well hydrated, and avoid personal triggers (often alcohol, very spicy or fatty foods, and lactose if intolerant). In remission, eat a balanced diet and treat anemia or iron deficiency and vitamin D deficiency.
A “permanent” cure is not typical without colectomy, but long, medication-maintained remission is very achievable.
Colon cancer risk rises mainly with extensive colitis and long disease duration (often after eight to 10 years) and with PSC (primary sclerosing cholangitis); good inflammation control and appropriate surveillance colonoscopy reduce risk.
I hope this helps you.
For further concerns, feel free to reach out to me anytime.
Thank you.
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Answered byDr. Syed Asif Rafiq
Medically reviewed byiCliniq medical review team
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