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What are the causes for chronic urticaria?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I am 36 years old and keep getting these itchy red welts on my skin, sometimes with no clear trigger. They come and go, and sometimes they last for hours or even days. It is uncomfortable, and antihistamines only work for a short time. Could this be chronic urticaria? What is causing it, and should I be worried about a serious allergic reaction? Are there long-term treatments that work without making me too drowsy?

Thanks.

Hi,

Welcome to icliniq.com.

I understand your concern.

The symptoms you are telling me feel like chronic urticaria or hives to me. It is a skin reaction that is caused by multiple factors:

  1. Allergy: Food allergies (such as peanuts, eggs, or shellfish), medications (like antibiotics or aspirin), insect bites, and airborne allergens (like pollen) can trigger hives.

  2. Infections: Bacterial, viral, fungal, and parasitic infections can lead to hives.

  3. Physical stimuli: Heat, cold, pressure, or even exercise can cause hives in some individuals.

  4. Other factors: Medications, autoimmune diseases, and certain medical conditions can also be triggered.

  5. Unknown causes: In many cases, the exact cause of hives is not known. It is not a serious allergic reaction, but it can be a symptom of anaphylaxis, a severe and potentially life-threatening allergic reaction.

Long-term treatment for chronic urticaria often involves non-sedating antihistamines, which do not typically cause drowsiness. Long-term treatment: Chronic urticaria, which is urticaria lasting for more than six weeks, can be managed with non-sedating antihistamines. These medications help reduce itching and the appearance of hives without causing drowsiness. Examples include Cetirizine and Loratadine.

When to seek medical help: If hives are accompanied by any signs of anaphylaxis, such as difficulty breathing or swelling of the tongue or throat, seek immediate medical attention. If hives persist despite treatment or if you have concerns about your symptoms, consult a doctor or allergist.

I hope this information will help you.

Thanks.

Medically reviewed byiCliniq medical review team

Published At September 14, 2025
Reviewed AtSeptember 15, 2025

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