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HomeAnswersHematologywhite blood cellsAre the Increase in WBC Count can be due to Neurontin?

Can Neurontin be the reason for high WBC count?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At July 22, 2016
Reviewed AtDecember 28, 2023

Patient's Query

Hi doctor,

My husband, who is 49, had blood work done. It shows a WBC count of 40,000, which has been checked twice now. His doctor wants to send him to see a specialist. He has had no recent infections. There is no change in his appetite and no weight loss. He feels fine.

He has been on Neurontin for three to five months now for neuralgia and in researching it; it says it can cause an increase in WBC count. He had been on Tegretol for neuralgia before. Could this cause it? Of course, our main concern is, could it be leukemia?

Answered by Dr. Prakash. H. M.


Welcome to icliniq.com.

Based on your query, my opinion is as follows:

Yes, Neurontin - Gabapentin is known to cause a high WBC (white blood cell) count. If there is no infection, then it is common to worry about leukemia when the WBC count is high. At present, the best idea is to get a peripheral blood smear report done.

If there is no increased immature form like blasts, then it is a Neurontin side effect. If immature blasts are present, then he will require further evaluation. The cause is probably Neurontin; however, get a peripheral smear to calm your mind.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Prakash. H. M.
Dr. Prakash. H. M.


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