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What Is Hemolysis?

Published on Jul 29, 2022   -  5 min read


As the name states, "hemo" and "lysis" refer to the act of breakdown of red blood cells. Read this article for a detailed analysis.



Hemolysis is an act of red blood cells being broken down or destroyed. This can be accounted as a basic human body function as well as a medical condition. Acting as body function, red blood cells are supposed to be broken down when it reaches their mature age or gets faulty or inefficient. On the other end, hemolysis exposes a medical condition of red blood cells being destroyed before they can be replaced.

Even though there are several causes for hemolysis, it can be collectively called an after-effect of hemolytic anemia. Normally red blood cells have a lifespan of 120 days. Once red blood cells reach this period, the spleen (an internal organ located near ribs to filter damaged red blood cells) will remove these red blood cells from the body. When someone is diagnosed with hemolytic anemia, the lifespan of red blood cells will be shortened. Still, the spleen will function like always and filter those red blood cells.

Here, the functioning of the spleen will become critical since they have to work more often than usual, which will eventually lead to life-threatening situations unless given proper attention and medication. Hemolysis can also occur due to certain medications.

What Does Hemolysis Mean?

Hemolysis is the rupture of erythrocyte membranes (known as the membrane of RBC), ultimately resulting in hemoglobin release. Hemolysis, often referred to as erythrocyte necrosis (a condition that has been linked to red blood cell damage), takes place at the termination of each erythrocyte's life.

What Are the Causes of Hemolysis?

The red blood cells usually die off when they become old and get replaced. Therefore hemolysis occurs in the body normally. Hemolytic anemia arises when the hemolysis causes a decrease in the number of red blood cells. Numerous factors, such as the following, could induce hemolysis to occur too quickly or too frequently:

What Are the Different Types of Hemolysis?

Hemolysis has been classified into three divisions based on grades of bacterial involvement and the destruction or breakdown of red blood cells. Before getting into the three types of hemolysis, we should get to know how the classifications are derived. As we stated above, bacterial involvement is a crucial part of the classification of hemolysis. The red blood cells which are affected by bacteria, release toxins that will be transferred to other cells. This bacterial involvement is differentiated using the blood agar test. Blood agar is a rich and complex solid medium used for the enormous growth of bacteria. As a result, blood agar helps in obtaining a diverse range of bacteria from limited samples. Blood agar is an artificially made medium with several chemical ingredients and rabbit or sheep blood, depending on the target bacterium.

Alpha hemolysis has a greenish nature while looking upon blood agar. So, if the blood agar results look greenish or brownish, it is said to be affected by alpha hemolysis. This greenish coloration is because the red blood cell hemoglobin will be converted to methemoglobin. Alpha hemolysis refers to whether someone is affected with partial hemolysis or incomplete hemolysis.

Beta hemolysis has a clear and evident bacterial infection when looked upon on the blood agar plate. Thus, beta hemolysis refers to a completely affected hemolysis scenario. Here, the release of toxins from bacteria will be on the higher side.

Gamma hemolysis refers to a non-hemolytic condition. There will not be any influential bacterial involvement for the first 24 hours when looked upon on the blood agar plate. Later after 24 hours, there is a slight chance for the presence of weak alpha hemolysis.

When Do the Symptoms of Hemolysis Appear?

The role of a doctor comes into the picture when someone feels the below-listed symptoms constantly. The symptoms of hemolysis are similar to hemolytic anemia. Here are a few symptoms commonly observed:

o Abnormal paleness.

o Yellowish skin and eyes.

o Increased levels of bilirubin.

How Is Hemolysis Treated?

Hemolysis does not have a recorded treatment protocol. The treatment completely depends on factors like:

After considering the above factors, one or more of the below treatment courses will be chosen by the healthcare provider.


Hemolysis is not a severe medical condition. It is a basic human body function, but it could get converted into a medical condition if not identified and given proper medical attention at the right time.

However, several medical conditions, medications, and substances might cause RBCs to degenerate early. When this happens, patients may develop anemia symptoms such as tiredness, dizziness, and headaches. In certain circumstances, the symptoms are more severe.

A severe version of hemolysis could bring down the life expectancy level. People cannot avoid being affected by this phenomenon; however, it can reduce the probability of being adversely affected by taking folic acid supplements, doing regular exercises, and doing routine health check-ups. A person who exhibits early signs of anemia should see a doctor for a prompt diagnosis and treatment.


Last reviewed at:
29 Jul 2022  -  5 min read




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