Diabetes Health

Connection Between Sedentary Lifestyle and Type 2 Diabetes Mellitus

Written by Dr. Shardendu Tomar and medically reviewed by iCliniq medical review team.


Our body uses the glucose with the help of insulin, which is synthesized in the pancreas and acts on the cell receptors, so that glucose gets entry into the cell for consumption. Diabetes is a disorder in which body is not able to use the glucose efficiently.

Once diabetes was considered as a disease of rich people, but nowadays it is seen in all classes of general population. One of the major causes of type 2 diabetes mellitus is wrong eating habits.

Foundation Period of Diabetes:

Just after the infancy period, mothers starts giving sweet products to their kids. The children become used to sweets and products high in sugar. It is seen that this is the time from which pro-glucose imbalance starts settling in the form of frequent insulin fluctuations and is the foundation period of diabetes mellitus type 2.

Role of Insulin:

When a food product is consumed, it is initially absorbed by GIT system. Then it reaches the blood and through which it will be available to pancreas and so insulin is secreted. Here, it is important to understand that in the blood there is always a constant amount of insulin. It is known as base levels of insulin. In response to food products it peaks in few hours and return back to base level in approximately 3 to 4 hours after consumption of food.

For a healthy metabolism, the insulin should reach to normal base levels after meals. But, unfortunately insulin hardly comes to base levels in most of the people nowadays, because they eat so frequently. Here, meal means everything which is eaten except plain water. Even a cup of tea is a meal, because it will cause a spike in insulin level. Ideally a person should eat three times a day and there should be a gap of at least 5 to 6 hours between meals, so that insulin could reach to normal base levels.


If a person keeps following frequent intake of meals, which causes hyperinsulinemia and at the same time the person is not so much physically active, then the blood sugar is not used. Also, we can say that it is not required by the cells and remains in blood causing hyperglycemia. As a result, our smart body starts down regulation of insulin receptors, which means a decrease in the number of insulin receptors. So, down regulation of insulin receptors occur as a result of inactivity and a sedentary lifestyle.

As the number of insulin receptors decreases, there is hyperglycemia in blood and most of the times for a sustained period after meals which is simply the starting phase of this disorder. This decrease in insulin receptors is a reversible condition for few years. If a person starts doing exercise in this phase, then again a phenomenon of up regulation is possible in which the normal number of receptors is restored in response to exercise. But, if the down regulation of insulin receptors remains as such for a few years, then permanent loss of receptors occurs and diabetes gets settled into body.

Why Diabetic People Always Feel Hungry?

People who are having high levels of insulin often feel hungry and keep eating. In our body there are two hormones, one is to start hunger and the other is for satiety. They are ghrelin and leptin respectively. Insulin is structurally similar to leptin. So, if a person having frequent high levels of insulin, then this insulin blocks those receptors in central nervous system on which usually leptin works and satiety is not felt. As a result a person does not feel satiety and eats more and produces more insulin, which again produces more hunger by not getting satiety. So, it is a vicious cycle which is very dangerous for the metabolism and is a main part in diabetes mellitus 2.

How to Prevent Diabetes?

As a preventive value I would emphasize that a person who is prediabetic still or is healthy,

  1. Should take their meals 3 to 4 times daily, strictly and should consume only water in between.
  2. Should exercise regularly to keep the insulin receptors in adequate numbers.

The above mentioned two things are important in preventing type 2 diabetes mellitus.

To gather more tips to prevent diabetes, consult a diabetologist online --> https://www.icliniq.com/ask-a-doctor-online/diabetologist

Last reviewed at: 07.Sep.2018



Do you have a question on Diabetes or Type 2 Diabetes Mellitus?
* guaranteed answer within 4 hours.

Related Questions & Answers

Why am I urinating more than 10 times a day?
Query: Hi doctor, I have to pee a lot of times a day though I do not have to wake up at night to go to the toilet. I have control over pressure, but I have to go more than 10 times a day. Also, I have to pass the stool after every meal. Why?  Read Full »
Dr. Salah Saad Shoman
Internal Medicine Physician

Answer: Hi, Welcome to icliniq.com. Please measure your fasting and postprandial blood glucose level as you might have diabetes. It is usually accompanied with increased thirst and increased hunger. Also, please get a urine analysis as you might have a urinary tract infection. It is usually accompanied with...  Read Full »
Is it fine to eat carbohydrates within 40 minutes after taking a GH shot?
Query: Hi doctor, Is it fine to eat carbohydrate and sugar within 40 minutes of growth hormone injection? Because, it is believed that after injecting growth hormone, a person should wait for at least 40 minutes to eat carbohydrate or sugar. Please explain.  Read Full »
Dr. Sumit Srivastava
Internal Medicine Physician

Answer: Hi, Welcome to icliniq.com. I can understand your concern. No, it is not advisable to eat carbohydrate and sugar for at least 60 minutes after taking a growth hormone shot. The more carbohydrate you consume, the higher your blood sugar will raise, which then set off insulin production. Insulin and ...  Read Full »
Diabetes Mellitus and Oral Health
Article Overview: This article emphasizes the impact of diabetes mellitus on oral health problems and its management.  Read Article »
Dr. Soheel Hussain Zargar

Diabetes mellitus is a metabolic disorder which affects the uptake and use of glucose by the human body. As a result, the glucose level in the blood rises beyond normal which has an overall impact on the general health and oral cavity. Types Of Diabetes Insulin-dependent diabetes mellitus: It oc ...  Read Article »

Ask a Doctor Online

* guaranteed answer within 4 hours

Related Tags