Published on Aug 31, 2019 - 4 min read
Lisinopril is an antihypertensive medication, which lowers blood pressure and reduces the risk of heart attack and stroke. Read the article to know more.
Lisinopril belongs to the group of drugs called ACE inhibitors, which is used to treat high blood pressure. Sometimes, it is also used in the treatment of heart failure. High blood pressure increases the risk of heart attacks, stroke, and kidney diseases. This drug reduces blood pressure by relaxing the blood vessels.
Points to Remember:
Lisinopril is used to treat hypertension.
This medicine increases your chance of surviving a heart attack.
It is available as an oral tablet and solution.
It is contraindicated during pregnancy or if you are trying to get pregnant.
This drug can cause angioedema, which can cause severe swelling of the face, arms, lips, tongue, and throat leading to breathing difficulty.
When you first start taking it, it can result in low blood pressure.
You might have persistent cough while on this medicine.
Avoid taking this medicine before or after 36 hours of using Sacubitril.
Do not use this with any medicine containing Aliskiren.
Potassium and creatinine monitoring are needed with this medicine if you have kidney disease.
Lisinopril is used alone or in combination with medicines to treat hypertension. High blood pressure can affect the heart and arteries, which in the long run, impairs their function. This damage to the blood vessels of the brain, heart, and kidneys, can result in stroke, heart failure, or kidney failure. Thus, using this medicine will reduce the risk of cardiovascular diseases.
It can also be used to treat heart failure, and in some patients after a heart attack. Some of the heart muscles are damaged and weakened after a heart attack, which makes it difficult for the heart to pump blood. Lisinopril is given for individuals with low heart function in order to preserve, improve or slow the progression of the disease.
In the renin-angiotensin-aldosterone system (RAAS), Lisinopril blocks the actions of angiotensin-converting enzyme (ACE), which prevents the conversion of angiotensin I to angiotensin II. This affects the adrenal cortex, which prevents the release of aldosterone. This action makes the kidney excrete sodium and retain potassium ions. This inhibition of the RAAS system lowers blood pressure and increases the supply of blood and oxygen to the heart.
Lisinopril is available in 2.5, 5, 10, 20, 30, and 40 mg strengths.
The dosage for high blood pressure is 20 to 40 mg taken once per day, up to 80 mg taken once per day.
The dosage for heart failure is 5 mg orally once per day, up to 40 mg taken once per day.
The dosage after a heart attack is 5 mg orally within the first 24 hours. Then if needed, another 5 mg after 24 hours. After this, 10 mg once per day for a minimum of 6 weeks.
It should be taken as prescribed by your doctor, and follow the instructions on the prescription label. Depending on how you react to the drug, your doctor might alter the doses. It can be taken with or without food. The solution form should be measured properly with a dose-measuring spoon or medicine cup. Your blood pressure, kidney function, and electrolytes need to be monitored regularly. Do not stop taking this medicine even after your blood pressure is under control, as it usually needs to be taken life long.
This drug should be avoided or taken under strict medical supervision if you have any of the following health conditions.
History of angioedema.
Prone to allergic reactions.
Trying to conceive.
Children below 6 years of age.
The common side effects include:
These side effects are usually mild and go away in some days. But if your symptoms are getting worse, get immediate medical help.
Some of the serious side effects include:
Allergic reaction -
Face, lips, tongue, and throat swelling.
Inability to swallow.
Nausea or vomiting.
Kidney disease -
Feet and ankles swelling.
Liver disease -
Abnormal liver enzymes.
Upper abdominal pain.
Nausea and vomiting.
Hyperkalemia (high potassium).
If you are profusely sweating or have vomiting or diarrhea while taking this medicine, you might get dehydrated, which increases the risk of hypotension and kidney failure.
Lisinopril can interact with other medications you might be taking, which might change the way the drug works. This can make the drug not work properly or cause unwanted side effects. To prevent this, always inform the doctor about all the medicines, herbs, and supplements that you are currently taking. The drugs with which Lisinopril can interact are:
Antihypertensive drugs -
Angiotensin receptor blockers (ARB) - Candesartan, Eprosartan, and Olmesartan.
Angiotensin-converting enzyme (ACE) inhibitors - Benazepril, Ramipril, and Captopril.
Renin-inhibitors - Aliskiren
Anti-diabetic drugs - Insulin and oral anti-diabetic drugs.
Diuretics - Hydrochlorothiazide and Furosemide.
Potassium-sparing diuretics - Spironolactone and Amiloride.
Nonsteroidal anti-inflammatory drugs (NSAIDs) - Ibuprofen and Naproxen.
Neprilysin inhibitors - Sacubitril.
Lisinopril is used for long-term treatment of hypertension. This drug if not taken as prescribed can cause serious side effects. If you stop taking it abruptly, your blood pressure might rise, which can increase your heart rate, cause sweating and anxiety. Taking it irregularly will not help control blood pressure, which puts you at higher risk for heart attack and stroke.
The doctor will monitor your blood pressure regularly and look out for any side effects. To know other ways to treat hypertension, consult a doctor online.
Lisinopril is not known to cause weight loss, but it can result in rapid weight gain. Contact your doctor if you rapidly gain weight or see swelling while taking this tablet.
Lisinopril does not make you sleepy or cause drowsiness. But, it might cause low blood pressure, which might result in lightheadedness or dizziness.
You can take this medicine at any time. As it can result in dizziness in the first few days of taking it, most doctors suggest you take Lisinopril before bedtime.
Taking a higher dose than prescribed can make your blood pressure to drop to dangerous levels. Hypotension can make you dizzy or faint. This leads to impaired blood circulation.
Some of the side effects of Lisinopril are lightheadedness, headaches, blurred vision, sweating, persistent cough, low blood pressure, and chest pain. It can also affect the kidneys, liver, and cause an allergic reaction.
Antihypertensive drugs, anti-diabetic drugs, diuretics, potassium supplements, Lithium, nonsteroidal anti-inflammatory drugs (NSAIDs), and Sacubitril should be avoided while taking Lisinopril.
Lisinopril and Ibuprofen can interact with each other, which reduces the action of Lisinopril in lowering blood pressure. Always consult your doctor before taking Ibuprofen, as he or she can alter the dose or prescribe an alternate drug.
The drug will start working in a couple of hours after taking it orally. But for the blood pressure to actually reduce, it will take around 2 to 4 weeks.
The half-life of Lisinopril that is the time taken for the concentration in the body to reach 50 % is 12 hours. So for the body to completely excrete it from the system, it might take around 28 to 88 hours.
Query: Hi doctor, I am currently taking Lisinopril for high BP. May I use a salt substitute to reduce magnesium level? Can I take Melatonin while on Lisinopril? Read Full »
Query: Hello doctor, I had a kidney transplant 17 years ago. My local doctor is on a trip overseas. So, I need some help. My only problem now is an increase in the BP. It shows 170/110 and the creatinine level is 1.7. This is the second time, I am getting such levels. Three years ago, I got the same. But... Read Full »
Do you have a question on Lisinopril or Lisinopril Side Effects?Ask a Doctor Online