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Platelet - Rich Plasma Therapy - Uses, Risks, and Side Effects

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Platelet-rich plasma (PRP) is a trending topic in cosmetology. Read the article to know about platelet-rich plasma protein therapy.

Medically reviewed by

Dr. Nagaraj

Published At February 6, 2023
Reviewed AtJanuary 3, 2024

Introduction:

The human body is designed in such a way that it can heal by itself. This fact has been implemented in platelet-rich plasma therapy, a form of regenerative treatment proven to produce growth factors naturally to heal the tissues.

What Is Plasma?

Plasma is the liquid portion of the blood acting as a medium for carrying red blood cells, white blood cells, and platelets throughout the body. In addition, it is composed of water and proteins.

What Are Platelets?

Platelets are one among the blood cells, also called thrombocytes. Platelets have a significant role in clotting blood. When the blood vessel gets damaged, the platelets receive signals from the body to reach the site, clump together, and clot the blood. Therefore, platelets are generally transfused to save the lives of people suffering from severe blood loss. In addition, the platelets can regenerate quickly and be donated every seven days.

What Is Platelet-Rich Plasma?

Platelet-rich plasma is a concentrated source containing growth and cellular signaling factors prepared from the individual’s platelets. The blood sample collected from the individual is subjected to centrifugation, which separates the blood into its components. The platelet-rich plasma is then obtained and injected into the area to be treated. The injection of platelet-rich plasma is guided using ultrasound for precise placement into the tissues.

What Are the Uses of Platelet-Rich Plasma Injections?

  • Skin Rejuvenation: Platelet-rich plasma therapy can reduce the early signs of aging by stimulating collagen production in the skin.

  • Hair Loss: Platelet-rich plasma injections help prevent hair loss and stimulate growth.

  • Osteoarthritis: In the case of osteoarthritis, the pain and inflammation around the joints can be healed by platelet-rich plasma injections.

  • Post-Surgical Healing: The post-surgical injuries are healed by placing platelet-rich plasma stitched along the surgical site.

  • Tendon, Ligament, Muscle, and Joint Injuries: Platelet-rich plasma injections can treat musculoskeletal injuries. For example, tendon injuries such as tennis elbows take a long time to heal. Platelet-rich plasma shots are given to fasten the healing process and reduce pain.

  • Fractures: Platelet-rich plasma injection is rarely used to heal broken bones.

How Do Platelet-Rich Plasma Injections Work?

The increased concentration of growth factors in platelet-rich plasma helps heal the tissues. The injured site can be healed using platelet-rich plasma injections in two ways. They are,

  • Platelet-rich plasma is injected directly into the injured area. For example, platelet-rich plasma in Achilles tendonitis is injected with a local anesthetic into the inflamed tissues to reduce inflammation and pain.

  • Platelet-rich plasma is also used to improve the healing of the surgical site. For example, an individual with a torn heel requires surgery. Recovery of the surgical site can be improved by treating using platelet-rich plasma injection during the surgery. The platelet-rich plasma is prepared uniquely to stitch it along with the torn tissues.

Who Is Not Indicated for Platelet-Rich Plasma Injections?

Although platelet-rich plasma is taken from the individual’s blood, it cannot be applicable for use in individuals with:

  • Abnormal platelet count.

  • Anemia.

  • Infection at the site.

  • Skin cancer.

  • Hepatitis C.

  • HIV (human immunodeficiency virus) or AIDS (acquired immunodeficiency syndrome).

  • Blood cancer.

  • Dermatological disorders.

  • Pregnancy.

  • Lactation.

What Are the Risks and Side Effects of Platelet-Rich Plasma Injections?

  • Platelet-rich plasma therapy is low-risk and does not cause serious side effects. However, the procedure involves drawing blood. Hence, the individual must be hydrated and should have eaten before the procedure to prevent feeling dizzy and lightheaded.

  • The individual may experience the sensation of burning and soreness at the injection site.

  • The risk of allergic reaction is low as the platelet-rich plasma injection is made from the own plasma and cells of the individual.

  • The common risks of platelet-rich plasma injections are bleeding, tissue damage, infection, and nerve injuries.

Is Platelet-Rich Plasma Injection a Permanent Solution?

A series of visits are required to obtain initial results. And after the results appear, touch-ups are needed at least once a year for the best results.

What to Do Before and After Getting Platelet-Rich Plasma Injections?

  • Before undergoing a platelet-rich plasma injection, the individual should stop medications such as Aspirin and Ibuprofen.

  • The individual should avoid taking vitamin and herbal supplements.

  • The individual should eat and drink adequate amounts of water to prevent lightheadedness.

  • The area treated should not be washed 48 hours after the injection.

  • The individual might feel sharp pain, soreness, and bruising in the treated site.

What Are the Precautions for Platelet-Rich Plasma Injection for Skin Rejuvenation?

  • The individual should clean the face but not apply makeup or other skin care products on the day of treatment.

  • The injected area must be iced once the treatment is complete to prevent bruises or burns.

  • Individuals with sensitive skin should thoroughly discuss the side effects before, during, and after the treatment.

  • The procedure involves a micro-needling process, so ample breaks must be given between treatments to allow skin healing.

  • Avoid doing any strenuous activity after the treatment is completed.

  • The individual can use a moisturizer and broad-spectrum sunscreen.

  • The individual should avoid excessive sun exposure.

What Are the Precautions for Platelet-Rich Plasma Injection for Hair?

  • The individual planning the procedure must wash the hair with a regular shampoo without using other hair care products.

  • Do not rub or touch the area to be treated for at least eight hours after the procedure.

  • Do not wet the hair three hours after the procedure.

  • For the first three days, using a pH-balanced shampoo is recommended.

  • Do not swim for at least two days after the treatment.

  • If the individual experiences pain and discomfort, Acetaminophen can be taken under the doctor’s supervision.

  • Applying ice to the area injected can reduce pain, swelling, and bruises.

Conclusion:

If an individual wishes to have a platelet-rich plasma injection, talking to the health care provider is essential to know the eligibility for the procedure. And the fact is that platelet-rich plasma injection is still under research for different applications in cosmetology. It is not like a drug prescribed by a physician, as it is derived from one’s blood.

Frequently Asked Questions

1.

Is PRP Painful?

Pain perception varies widely among individuals. Patients might feel pain while collecting blood samples and during injecting the PRP into the scalp. Mild to moderate pain can be experienced by the patient for 1 or 2 days, but this pain can be well tolerated. Soreness, bruising, redness, and swelling can be seen at the injection site, but this subsides within 3 to 7 days.

2.

At What Age PRP Is Suggested?

Middle aged people (18 to 45) are suggested for PRP treatments. The age of the patient is greatly related to the platelet concentration; as age increases, there is a gradual loss of structure and function of platelets, which, in turn, affects the platelet concentration. Decreasing platelet concentration could lead to poor outcome of results. Hence, PRP is not very successful in elderly people.

3.

Can Everyone Undergo PRP?

PRP is not suitable for everyone. PRP should be performed only by a qualified healthcare professional. Before undergoing PRP, certain laboratory tests like blood investigations must be advised to the patient to assess the health condition. Persons with bleeding disorders (anemia, leukemia), autoimmune disorders, persons with ongoing cancer treatments, and pregnant women are not indicated for PRP.

4.

Is Walking Recommended After PRP?

Patients can absolutely return back to their daily life activities after PRP. As the Persons experience mild pain during PRP injections, it is advised to take rest for 24 hours post treatment. Once the pain subsides, the patient can continue with walking and physical activity and can exercise regularly. But in some patients, the recovery time may last from 3 to 5 days.

5.

Will PRP Show Its Effect on the Brain?

Platelet-rich plasma contains numerous growth factors that help in the regeneration and repair of the tissues. Hence, this can be used in treating injuries of the central nervous system. PRP can be safely used in treating inflammatory (swelling, pain) conditions of the brain. However, further clinical research is needed to approve the use of PRP in treating brain injuries.

6.

Does PRP Cause Any Injury to Nerve?

 
Nerve damage is considered a minor complication of PRP, which is encountered during blood drawing. However, PRP is considered the revolution in treating neuropathy (nerve damage). PRP helps in the healing and repair of injured nerves, thus improving nerve conduction (function) and relieving pain.

7.

Can PRP Damage the Heart?

 
PRP can be the treatment option in a wide variety of conditions. PRP for hair growth does not show any ill-effects on the heart. Cardiac surgeons are using PRP in heart transplant surgeries and also in the reconstruction of blood vessels that are removed during bypass surgery. One of the major advantages is that there will be no rejections and reactions when patients' own blood is used for PRP.

8.

Will Plasma in PRP Have Prolonged Side Effects?

 
Plasma in PRP does not cause any long lasting side effects since the person's own plasma is used in PRP sessions.  But in some cases plasma is taken from the donors and used for treatment.  Plasma donors may experience side effects like weakness, fainting, dryness of mouth and bruising. In rare instances serious complications such as infections and reactions can occur which should be addressed immediately.

9.

When Can One Stop Taking PRP Sessions?

 
PRP prevents hair fall and helps in hair regrowth; the number of sessions depends on the requirements of the patients, and then, according to the condition, the doctor recommends the treatment plan. When once the person completes the treatment, it is advised to take multiple sessions of PRP to maintain the results obtained through PRP.

10.

What Happens When a Person's Stops Receiving PRP Injections for Hair Loss?

 
PRP treatment enhances the blood supply to prevent hair fall and provides growth factors for hair regrowth. When once the treatment is stopped there will be progressive loss of blood flow and growth factors for the hair follicles. PRP results are not permanent but they are long lasting. However Stopping the PRP treatment will not worsen the condition than before the treatment.

11.

Can Hair Regrow After PRP?

PRP is used to treat both male and female patterns of baldness. This can be done singly or in combination with hair transplantation for better results.PRP treatments are likely to prevent hair fall and promote regrowth of hair. However, the regrowth of hair is influenced by many factors, such as age, pregnancy, and underlying disorders. For example, cancer treatment can lead to alopecia (baldness), which can sometimes be permanent (irreversible).

12.

What Are the Food Restrictions After Treating With PRP?

Foods that reduce the platelet count must be strictly avoided during the PRP treatment. These foods include carbonated beverages containing quinine, alcohol and smoking. Alcohol should be strictly avoided during treatment as it decreases the platelet production and the produced platelets appear to be abnormal.

13.

How Many Sessions Can PRP Be Done in a Year?

 
PRP sessions are advised once in every 21 days or 2 to 3 weeks, usually the doctor advises the number of sessions depending on the hair fall and requirements of the patients. When PRP treatment is completed the doctor advises to take a booster dose of PRP once every 6 months to 1 year. Booster dose helps as the maintenance phase of the therapy, which is very important to retain the hair.

14.

Does PRP Subsides the Knee Pain?

PRP shows good results in case of knee joint pains.  PRP reduces the pain and improves the functional ability of the joints. It is a traditional method of treating osteoarthritis (a degenerative joint disease that causes pain and inflammation of joints, osteoarthritis generally affects the joints of knees, hip and fingers).

15.

How Can One Get Best Results for PRP?

Maximum results from PRP can be obtained by following simple tips like:
- Regular exercise.
- Improving vitamins and iron intake.
- Strictly following post operative instructions.
- Stop smoking and alcohol intake.
- Avoiding  Aspirin prior to the procedure.
- Keeping oneself well hydrated.
By following these instructions one would enjoy the maximum results of PRP.

16.

At What Depth Can the Needle Be Penetrated for Injecting PRP?

PRP (platelet-rich plasma) is performed by using microneedling (a procedure that uses small sterile needles for pricking the skin or scalp). Insulin syringes are commonly used in microneedling. The recommended depth of the needle for delivering the PRP is 1.5 to 2.5 millimeters.

17.

How Successful Is PRP?

PRP is successful in treating hair loss. It works by preventing hair fall and stimulates the production of new hair. PRP is also advised in cases of hair transplantation. After hair transplantation, PRP injections are advised to promote hair growth. However, the success rate depends upon many factors like age, health conditions (diabetes, hypertension), and medications that are used by the patient.
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Dr. Nagaraj
Dr. Nagaraj

Diabetology

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