Amniocentesis

Amniocentesis is a procedure where the amniotic fluid, which is the fluid that surrounds and protects the baby during pregnancy, is collected from the uterus for testing or treatment. It is used to diagnose fetal infections or for genetic testing or fetal lung testing. It is also used as a treatment for polyhydramnios (too much accumulation of amniotic fluid during pregnancy).

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What does my double marker blood test indicate?

Query: Hi doctor, I am 12 weeks 5 days pregnant. I got my NT scan and double marker blood test results. NT value 1.1 mm, free b-hCG 1.52 MOM, PAPP-A 0.37 MOM, trisomy 21+NT risk 1:1132, trisomy 21 1:169, trisomy 13/18+NT. In urine culture, there is no significant growth observed after 48 hours. I am curre...  Read Full »


Dr. Jimesh H Mavani

General Practitioner, Obstetrician And Gynaecologist

Answer: Hello, Welcome to icliniq.com. I have seen the report completely (attachment removed to protect patient identity). Your report is normal and there is no need to worry. If you want a detailed explanation about the report, then here you go. There are some genetic syndromes, which are happening worl...  Read Full »

Can you please help me interpret my NT scan report?

Query: Hello doctor, I am a 44-year-old female. After my three miscarriages, I am 13 weeks pregnant now with IVF treatment. I have got my NT scan with double marker blood test. The results are as follows: Biochemical Trisomy 22 risk: 1:249, combined Trisomy 21 risk. Using NT & Other parameters: 1:946...  Read Full »


Dr. Sameer Kumar

Family Physician, Obstetrician And Gynaecologist, Infertility Specialist

Answer: Hello, Welcome to icliniq.com. The NT (nuchal translucency) scan levels of nuchal translucency are normal with NT < 2.5 mm. However biochemical trisomy 21 risk is high but the combined NT+ biochemical risk is low at 1:946. You may upload the picture of the cutoff graph for a convincing opinio...  Read Full »

Can pregnancy be terminated in the 28th week?

Query: Hi doctor, I am in my late 6th month pregnancy. Recently I went for a scan named targeted imaging for fetal anomalies (TIFFA). All the reports were normal except hypoplastic nasal bone and higher normal values of amniotic fluid. I am approaching you for second consultation now. My questions are, wh...  Read Full »


Dr. Muhammad M. Hanif Md.

Cardiologist, Criticalcare Physician, General Medicine Physician, Internal Medicine Physician

Answer: Hi, Welcome to icliniq.com. I have thoroughly gone through your case and can well understand your genuine health concerns.  Read Full »

My trisomy 21 report value is 1:250. Was it normal?

Query: Hi doctor, I am 12 weeks 5 days pregnant. My NT scan measures 1.6 mm, the double marker PAPP-A is 2.82, and free beta hCG is 36.7 Could you please help with the report? Was it normal? My trisomy 21 is 1:250.  Read Full »


Dr. Nadia Khan

Obstetrician And Gynaecologist

Answer: Hello, Welcome to icliniq.com. 1 in 250 is a high risk for trisomy which means your risk of having a baby with trisomy 21 is 1 out of 250. But this test is only a screening test which means that they just calculate the risk of having a baby with down syndrome. If someone is found at higher risk li...  Read Full »

Other than ultrasound, how can Down's syndrome be diagnosed?

Query: Hi doctor, I am 26 weeks pregnant. Yesterday, I went for an ultrasound scan named targeted imaging for fetal anomalies. Other than hypoplasia of nasal bone, everything is normal. I need an expert opinion regarding advanced tests of ultrasound or amniocentesis, karyotyping or any ultrasound scan to ...  Read Full »


Dr. Sameer Kumar

Family Physician, Obstetrician And Gynaecologist, Infertility Specialist

Answer: Hi, Welcome to icliniq.com. I have gone through your reports (attachment removed to protect patient identity) in toto. At 26 weeks period of gestation, the overall growth of the fetus is fine. But the concern here is hypoplastic nasal bone seen in the second trimester TIFFA (targeted imaging for ...  Read Full »

In my 18th week of pregnancy, clubfoot was diagnosed. Should I undergo amniocentesis?

Query: Hi doctor, I am in my 18th week of pregnancy. The fetus has been diagnosed with clubfoot when I went for an anomaly scan on the 16th week. There is no other anomaly diagnosed so far. Please let me know if I have to undergo amniocentesis to rule out other associated anomalies. If I am not wrong, I ha...  Read Full »


Dr. Jyoti Gupta

Infertility Specialist, Obstetrician And Gynaecologist

Answer: Hi, Welcome to icliniq.com. Clubfoot (twisted foot) is not an uncommon anomaly and its prognosis is good. It means, it is correctable in most cases. Amniocentesis is an invasive procedure. If you have already undergone biochemical markers like a dual marker or triple test and they are negative, then...  Read Full »

Is nasal bone length an indicator of Down's syndrome?

Query: Hi doctor, My quadruple test is normal. After 23 weeks of gestation, I took an anomaly scan, which shows 3.6 mm nasal bone. Is the nasal bone underdeveloped? What are the chances of Down's syndrome? We do not want to get an amniocentesis test done as it increases the chance of miscarriage. Previous...  Read Full »


Dr. Sameer Kumar

Family Physician, Obstetrician And Gynaecologist, Infertility Specialist

Answer: Hi, Welcome to icliniq.com. The nasal bone thickness is relevant only between 11 to 13 weeks pregnant scan where it should be less than 2 mm. Nasal bone thickness at 23 weeks gestation is irrelevant. If the quadruple test shows low risk of Down's syndrome, then amniocentesis is not recommended. How...  Read Full »

What is the use of quadruple marker test?

Query: Hello doctor, My wife is 18 weeks pregnant with twin gestations. She has conceived through IUI treatment. We want an urgent and detailed feedback regarding her quadruple marker report. How authentic are the report findings, considering there are no other marker tests done before, like double marker...  Read Full »


Dr. Deepti Verma

Fetal Medicine Specialist, Obstetrician And Gynaecologist

Answer: Hi, Welcome to icliniq.com. I have gone through your question and understand your concerns. I have reviewed the quadruple marker report (attachment removed to protect patient identity). First of all, any serum screening like double or quadruple marker does not accurately assess the risk of chromosom...  Read Full »

The scan says my baby's growth is 10 days behind its age. Please advise.

Query: Hi doctor, I am a 35 year old female. I am 22 weeks and two days pregnant and was told at my last scan that the baby is about 10 days behind in size. All the other readings were normal, and the growth of the brain was normal for the gestational age. We are not very tall people. My husband is 5 feet...  Read Full »


Dr. Sanjay Kumar Bhattacharyya

Obstetrician And Gynaecologist

Answer: Hello, Welcome to icliniq.com. I can understand your concern. There is always some discrepancy while trying to assess the fetal age by ultrasonography (USG) and comparing it with your last menstruation period date. The discrepancies are: In a USG done in the first three months, there is a discrepa...  Read Full »

Do my wife's NT scan and double marker test results show a high risk for Down's syndrome?

Query: Hi doctor, My wife had NT scan and double marker test at 12 weeks and 3 days of pregnancy. The report is as follows, CRL is 59.2 mm, NT is 1.45 mm, free beta-hCG is 84.84 IU/L, equivalent to 2.217 MoM and PAPP-A 0.712 IU/L equivalent to 0.282 MoM. Trisomy 21 is 1: 450 1:47 and trisomy 18 is 1: 5315...  Read Full »


Dr. Deepti Verma

Fetal Medicine Specialist, Obstetrician And Gynaecologist

Answer: Hi,Welcome to icliniq.com.I have read your question and understand the concerns.The report is showing a high risk for trisomy 21 or Down's syndrome. This first-trimester screening is 95 % sensitive, hence, if the risk is positive, then the amniocentesis should be done to confirm the fetal karyotyp...  Read Full »

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Disclaimer: All health Q&As published on this website is not intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek the advice from your physician or other qualified health-care providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website.