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HomeAnswersPsychiatryanxiety disorderDespite taking antidepressants, I have been experiencing depression and anxiety for a long time. Please help.

How can someone overcome the anxiety and depression that do not go away with medications?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At November 26, 2022
Reviewed AtSeptember 26, 2023

Patient's Query

Hello doctor,

I have been battling depression and anxiety for a long time. I have been going in and out of doctors for ten years, and they have been giving me antidepressants that never worked; I have tried a lot and blamed myself for them not working. Finally, I recently took a neurotransmitters test that did not return serotine imbalance, so they gave me antidepressants. Instead, it came back as GABA imbalance and low glutamate imbalance; I am stuck on what to do, it has been getting worse, and I feel like I have wasted ten years of my life; I feel like I have to do something about it now.


Welcome to icliniq.com.

I understand your concern.

Anxiety disorders follow a chronic course, and the anxiety tends to relapse with time. So even if you are taking medicines regularly, symptoms can relapse. Treatment of anxiety includes behavior therapy and medicines. SSRIs (selective serotonin reuptake inhibitors) are commonly used for anxiety and help reduce anxiety and restlessness. Behavior therapy like relaxation exercises, breathing exercises, yoga, and progressive muscle relaxation exercises help supplement the drugs' actions. So please do not lose hope and continue to take your medicines regularly.

I hope you find it helpful.

Kind regards.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Seikhoo Bishnui
Dr. Seikhoo Bishnui


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