I have been having terrible problems with anxiety and depression. I was on Trepiline and Eltroxin for depression when I was younger and I mainly want to know if I can substitute St John's wort for 25 mg Trepiline? These episodes definitely worsen around my period, so might a vitamin B supplement help? I am 35 years old. So far I have been managing this with breathing techniques, mindfulness, etc., but I really cannot carry on like this anymore. Please help.