Beta Thalassemia

Beta thalassemia is a blood disorder where there is abnormal hemoglobin production. It is caused due to mutation in the hemoglobin beta gene. There are three types of beta-thalassemia. They are beta thalassemia minor, beta thalassemia intermedia, and beta thalassemia major. Depending on the type of beta-thalassemia, the symptoms can be minor or severe. The signs and symptoms are shortness of breath, pale skin, tiredness, increased heart rate, and yellowish discoloration of eyes and skin. Taking regular blood transfusions along with medications helps to manage it.

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Husband has beta thalassemia trait and wife is not a carrier. Is it safe for the baby?

Query: Hello doctor, I have done a pre-marital test with a prospective groom and he has beta thalassemia trait and I am not a carrier. Is it safe for pregnancy and child? His hemoglobin count is 13.1 and HbA2 is 5. How safe is this for child's health?  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to Following is my opinion for your asked question. If you are not having beta thalassemia minor then no need to worry. Your future child can have thalassemia minor. But no need to worry for trait of thalassemia minor. Thalassemia major is the dangerous one in which lif...  Read Full »

Is my friend's beta thalassemia screening test normal?

Query: Hello doctor,My cousin of 30 years old got tested for beta thalassemia screening test. He got the result as hemoglobin A2 is 2.8 %, hemoglobin F is 0.2 %, and hemoglobin C, D, and S are not detected. Is this normal or has any complications?Please guide.  Read Full »

Dr. Prakash H. M

Answer: Hi, Welcome to Based on your query, my opinion is as follows: The beta-thalassemia screening test appears to be normal. HbA2 levels (hemoglobin A2) are normally between 2 to 3.3% and HbF levels (fetal hemoglobin) are 0.1 to 1.2% for this age. Both are normal. The other hemoglobin typ...  Read Full »

Is beta thalassemia trait a serious case?

Query: Hello doctor, Is beta thalassemia trait a serious case?  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to Let me explain to you about the beta thalassemia trait. It is good that you are aware of using online health portals. Beta thalassemia trait is a heterozygous condition and the patient can live a normal life. If nutrition is not maintained properly and if any unusual ...  Read Full »

Am I a beta-thalassemia carrier with the hemoglobin A2 level of 4.3?

Query: Hello doctor, I was just wondering for a second opinion on some results which I have received being 8+4 weeks pregnant. My FBC was normal but my hemoglobin A2 Level is 4.3 and it says the normal range is 1.5 to 3.6. But I just wanted to know if this definitely means I am a carrier of beta-thalassem...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to Your attached CBC report shows normal hemoglobin and MCV with RBC count is also within range (attachment removed to protect patient identity). I have calculated the Mentzer index as well which is also not in favor of thalassemia minor. Moreover, in the report also it has ...  Read Full »

Can beta-thalassemia minor be treated?

Query: Hi doctor, One of my daughters has got beta thalassemia major and G6PD deficiency. Is there any treatment for her? Please advice.  Read Full »

Dr. Geetha Priyadarsini Kamminana

Answer: Hello, Welcome to Beta thalassemia major includes a hereditary disorder and is due to genetic deficiency of beta globin chains of hemoglobin. It is transfusion dependent anemia. Management of beta thalassemia major includes Chronic transfusion to maintain hemoglobin at the range of...  Read Full »

Kindly go through my blood report and suggest the type of thalassemia.

Query: Hi doctor,I have attached a report. I just want to know if this hemoglobin electrophoresis result is beta thalassemia minor or beta thalassemia intermedia or beta thalassemia major.  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to According to HPLC report (high-performance liquid chromatography), you have attached, HbA2 raised and HbA decreased (hemoglobin A2 and A). Hence, it is suggestive towards thalassemia minor (attachment removed to protect patient identity).It does not look like thalassemia ...  Read Full »

What does my blood report suggest about beta-thalassemia?

Query: Hello doctor, I have beta-thalassemia. My doctor ordered some blood tests and the reports are as follows: 1. Iron saturation - 9 micromol/L. 2. Vitamin B12 - 1960 pg/mL. 3. Folate - 14.2 ng/mL. 4. Ferritin - 8 ng/mL. 5. HbA1c - 5.8 %. 6. Hemoglobin - 10.2 g/dL. 7. RDW - 21.8 % I am taking Losartan ...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to I read your query and understand your concern. As per the attached report (attachment removed to protect the patient's identity), iron saturation, ferritin, and hemoglobin with MCV (mean corpuscular volume) are low. So secondary iron deficiency anemia might be prese...  Read Full »

Does the relationship DNA test get affected by beta-thalassemia minor?

Query: Hi doctor, I am beta thalassemia minor. If I go for a relationship DNA test with my son, will the DNA report be false due to this?  Read Full »

Dr. Prakash H. M

Answer: Hi, Welcome to Based on your query, my opinion is as follows: No, relationship DNA test will not be affected. It is autosomal related. He may or may not be a carrier. DNA test will look at multiple patterns. If you want, you can go for DNA test. Being affected from thalassem...  Read Full »

Is it rare to see sickle cell anemia and beta thalassemia together?

Query: Hi doctor, My friend is 26 years old. He has sickle cell anemia and thalassemia together. His recent spleen health was good and the proportion of blood and iron was moderate. He does not need to increase the blood. Is it rare to see these two together? What is the average life expectancy of these p...  Read Full »

Dr. Veerendra Channabasappa Patil

Answer: Hello, Welcome to As per your description, your friend seems to be having sickle beta thalassemia. It is common to see both these diseases together in communities where both the diseases are prevailing. Actually, the severity of sickle cell disease comes down by elevation of ...  Read Full »

I am a 25-year-old female with beta thalassemia trait. What precautions should I take to avoid giving birth to a thalassemia major child?

Query: Hello doctor, I am a 25-year-old female and have had beta thalassemia trait for the last ten years. My doctor told me to marry a guy with a negative blood group because my blood group is O-positive. Is it to prevent our child not being affected by thalassemia? So what do I do now? Avoid marriage o...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to You should try to avoid marriage with a thalassemia minor patient to avoid a thalassemia major child. To rule out thalassemia minor, investigate your partner by hemoglobin (HB) electrophoresis using by HPLC (high-performance liquid chromatography) method. You can ma...  Read Full »

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