CALR Exon 9 mutation is detected. Do I have to worry?

Question

Hello doctor,

I am a 46-year-old male. A month ago, I had a heart stroke and underwent an angiogram for a blood clotting thrombus. My CBC report at that time shows a platelet count of 24 lakhs.

I received the CALR Exon 9 mutation analysis report today. It reads, "CALR Exon 9 mutation is detected by PCR amplification of Exon 9 of CALR, followed by sequencing of the coding and junctional region of the Exon. A hematologist prescribed me Anagrelide 0.5 mg.

Do I have to worry? Can it be cured by medication?

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

You have very high levels of platelet count, which is called 'primary thrombocytosis' or 'essential thrombocytosis,' which was confirmed by the CALR Gene mutation test. This condition will result in either clots or sometimes bleeding in any part of the body.

There are a few treatment options available to control the disease. Anagrelide is one of them, which is supposed to be taken along with Aspirin.

Please consult a hematologist who will monitor the condition and give you treatment.

I hope this helps.

Please revert in case of further queries.

Thank you.