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CALR Exon 9 mutation is detected. Do I have to worry?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am a 46-year-old male. A month ago, I had a heart stroke and underwent an angiogram for a blood clotting thrombus. My CBC report at that time shows a platelet count of 24 lakhs.

I received the CALR Exon 9 mutation analysis report today. It reads, "CALR Exon 9 mutation is detected by PCR amplification of Exon 9 of CALR, followed by sequencing of the coding and junctional region of the Exon. A hematologist prescribed me Anagrelide 0.5 mg.

Do I have to worry? Can it be cured by medication?

Please help.

Thank you.
Answered by Dr. Mohammed Parvez

Education:

MBBS

Professional Bio:

Dr. Mohammed Parvez is a General Practitioner skilled in providing primary healthcare services for patients of all ages. He is experienced in diagnosing and treating common illnesses, managing chronic conditions, offering preventive health advice, and coordinating specialist care when needed. His approach emphasizes holistic treatment, patient education, and fostering long-term health.

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Hello,

Welcome to icliniq.com.

You have very high levels of platelet count, which is called 'primary thrombocytosis' or 'essential thrombocytosis,' which was confirmed by the CALR Gene mutation test. This condition will result in either clots or sometimes bleeding in any part of the body.

There are a few treatment options available to control the disease. Anagrelide is one of them, which is supposed to be taken along with Aspirin.

Please consult a hematologist who will monitor the condition and give you treatment.

I hope this helps.

Please revert in case of further queries.

Thank you.

Medically reviewed by Dr. K. Shobana
Published At April 30, 2018
Reviewed At April 30, 2026

Education:

MBBS

Professional Bio:

Dr. Mohammed Parvez is a General Practitioner skilled in providing primary healthcare services for patients of all ages. He is experienced in diagnosing and treating common illnesses, managing chronic conditions, offering preventive health advice, and coordinating specialist care when needed. His approach emphasizes holistic treatment, patient education, and fostering long-term health.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Education:

BDS

Professional Bio:

Dr. K. Shobana is a Dental Surgeon specializing in oral health and dental care. She is skilled in preventive dentistry and provides oral hygiene education. She can do restorative treatments such as fillings and crowns. She can handle periodontal problems such as gum diseases and periodontitis. She can do root canal treatment.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Mohammed Parvez
Dr. Mohammed Parvez

Internal Medicine

Education:

MBBS

Professional Bio:

Dr. Mohammed Parvez is a General Practitioner skilled in providing primary healthcare services for patients of all ages. He is experienced in diagnosing and treating common illnesses, managing chronic conditions, offering preventive health advice, and coordinating specialist care when needed. His approach emphasizes holistic treatment, patient education, and fostering long-term health.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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