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Q. CALR Exon 9 mutation is detected. Do I have to worry?

Answered by
Dr. Mohammed Parvez
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Apr 30, 2018

Hello doctor,

I am a 46-year-old male. A month ago, I had a heart stroke and underwent angio for blood clotting thrombus. My CBC report at that time shows a platelet count at 24 lakhs. I received CALR Exon 9 mutation analysis report today. It reads "CALR Exon 9 mutation is detected by PCR amplification of Exon 9 of CALR, followed by sequencing of coding and junctional region of the Exon. The sequence is compared with the reference sequence NM-004343 for the analysis of mutations." Hematologist prescribed me Anagrelide 0.5 mg. Do I have to worry? Can it be cured by medication?

Dr. Mohammed Parvez

General Medicine Internal Medicine


Welcome to

You have very high levels of platelets which are called 'primary thrombocytosis' or 'essential thrombocytosis', which was confirmed by CALR Gene mutation test. This condition will results in either clots or sometimes bleeding in any part of the body.

There are few treatment options available to control the disease, Anagrelide is one of them, which is supposed to be taken along with Aspirin. Please consult a hematologist who will monitor the condition and give you treatment.

Please discuss with the hematologist if you can be tried on Hydroxyurea instead of Anagrelide which is a better drug.

For more information consult an internal medicine physician online -->

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