Essential Thrombocytosis

Essential thrombocytosis is otherwise called primary thrombocytopenia. This is a rare disorder affecting the body, and there is abnormal production of platelets. It can cause abnormal blood clotting or bleeding. It occurs due to exposure to chemicals or electrical wiring. The symptoms are bleeding, headache, vision disturbance, easy bruising, gastrointestinal bleeding, and coldness in the fingers. Taking low-dose Aspirin reduces the risk of having blood clotting, platelet lowering medications, and plateletpheresis are done to manage this condition.

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Why is the platelet count high in a baby?

Query: Hello doctor,My 12-month-old baby girl got high platelet in her anemia blood test. Her hemoglobin and WBC are normal, her platelet was 1170. After three days we made a test again and got the result 960. What can I do now, Baby is fine. No unusual symptoms. Sometimes, she gets cold and fever but that...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to Your child's liver, spleen, and lymph nodes should be palpated to check for any enlargement, if present. Thrombocytosis is usually considered reactive when decreasing with time. Your child's platelet reduces in three days so mostly it will be reactive secondary high pl...  Read Full »

Why do my reports show low hemoglobin and high platelet count?

Query: Hi doctor,My platelet count is going higher and my hemoglobin is getting low. I feel sick. My report showed a platelet count of 5,85,000 and Hb of 10.6. What could be the reason?  Read Full »

Dr. Prakash H. M

Answer: Hi, Welcome to Based on your query, my opinion is as follows: Mild bleeding or ongoing inflammation could be a cause. Any blood in stools or tarry stools or if there is any fever, then it requires evaluation. You need to check ESR (erythrocyte sedimentation rate) and C-reactive prot...  Read Full »

What are the reasons for high platelet count?

Query: Hi doctor, I am a 46-year-old diabetic female. My platelet count is high at 900,000 per microliter of blood in routine CBC. My iron is normal. My USG showed hepatosplenomegaly and PBS showed microcytic hypochromic anisocytosis. What shall I do now?  Read Full »

Dr. Veerendra Channabasappa Patil

Answer: Hello, Welcome to The platelet count is above the normal range. There are many reasons for such elevated platelet count. It needs further investigations, including genetic tests. The conditions like essential thrombocytosis could be considered with the available information from you....  Read Full »

Can I take Hydroxyurea for thrombocythemia?

Query: Hello doctor,I am 25 years old. I have been diagnosed with essential thrombocythemia. The reasons are elevated platelet count (about 700,000 to 900,000 platelets per microliter of blood), positive JAK2 V617F mutation analysis, etc. Different opinions are coming from doctors in my country. Avoiding d...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to I can understand the situation through which you are going. I have reviewed your query and below is my advice for your case. Usually, in the case of essential thrombocythemia, there is no need to undergo treatment with Hydroxyurea in all cases of ET (essential thro...  Read Full »

CALR Exon 9 mutation is detected. Do I have to worry?

Query: Hello doctor, I am a 46-year-old male. A month ago, I had a heart stroke and underwent angio for blood clotting thrombus. My CBC report at that time shows a platelet count at 24 lakhs. I received CALR Exon 9 mutation analysis report today. It reads "CALR Exon 9 mutation is detected by PCR amplificat...  Read Full »

Dr. Mohammed Parvez

Answer: Hello, Welcome to You have very high levels of platelets which are called 'primary thrombocytosis' or 'essential thrombocytosis', which was confirmed by CALR Gene mutation test. This condition will results in either clots or sometimes bleeding in any part of the body. There are few t...  Read Full »

What does elevated platelet count indicate?

Query: Hi doctor,I am a 27-year-old female. I have dyslipidemia and currently taking Lipanthyl. I have been taking blood tests and consult my doctor every month for five months. I manage to reduce my cholesterol, but the doctor is concerned with my platelet count right now. I have attached my blood platele...  Read Full »

Dr. Mubashir Razzaq Khan

Answer: Hello, Welcome to In the case of elevated platelets, grade 1 thrombocytosis: platelets range between 550-649. In grade 2, thrombocytosis: platelets range between 650-749. Grade 3 thrombocytosis: 750-849. Grade 4 thrombocytosis: 850-1099. Grade 5 thrombocytosis: 1100 or more. Elev...  Read Full »

Why do I have elevated platelet levels?

Query: Hi doctor, My platelets were 468 last month, and I repeated another full CBC. Everything else was fine, but my platelets were still 463 a month later. Is this something to worry about? I have fatty liver grade 1 and mild IBS. I also had a Coronavirus infection two months ago. Currently, I am on m...  Read Full »

Dr. Mubashir Razzaq Khan

Answer: Hello, Welcome to Elevated platelets indicate the following conditions: Grade 1 thrombocytosis: platelets 550-649. Grade 2 thrombocytosis: platelets 650-749. Grade 3 thrombocytosis: platelets 750-849. Grade 4 thrombocytosis: platelets 850-1099. Grade 5 thrombocytosis: platelets 1...  Read Full »

What could be the reason for my high platelet levels?

Query: Hello doctor, I have migraines for months was put on medication, but it was not helping. Now I am on preventative and emergency medicines. I have done an MRI, which showed abnormal results. Blood work showed platelets of 544. I was asked to consult a hematologist. What can it be?  Read Full »

Dr. Kapil Kumar Gupta

Answer: Hello, Welcome to I have reviewed the reports of your MRI (magnetic resonance imaging) and blood (attachment removed to protect patient identity). They are incomplete reports, and I would like you to share the other sections of the reports as well for me to have a clear picture. Well...  Read Full »

Will thrombocytosis cause headache with rapid heart beat?

Query: Hi i need medical assistance when it comes to my blood. My friend which is an emergency doctor suspected that i might have Thrombocytosis. I am so worried cause i keep on having tachycardia, as if my heart is having hiccups and it beats so fast. I always feel either dizzy or i have headaches. I'm so...  Read Full »

Dr. Prathish Kumar

Answer: Hello I understand youbare worried about your blood test results..I have gone thorugh your investigation reports..More than a slight increase in platelets, there are other findings abnormal in peripheral smear. Presence of rouleaux formationbusually occurs in a condition called Multiple myeloma and...  Read Full »

Does the presence of JAK2 gene mutation automatically rule out CML?

Query: Hi doctor, My platelet has always been high in the range of 600 to 700 x 10"9/L. My other blood count is within the normal range as of today. Ten years ago, I had two BCR or ABL test (peripheral blood) to rule out CML; one test came back positive, the other negative. Which test should I believe? Th...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to I can understand your concern. Do not worry. I will try to answer all of your questions. Following is my answers and opinion to your questions. RT PCR (Reverse transcriptase-polymerase chain reaction) is a highly accurate test to check BCR ABL mutation to rule out...  Read Full »

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