Dr. Goswami Parth Rajendragiri
Pathology
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Patient's Query
Hello doctor,
My 72-year-old father has a weak heart and was diagnosed with CML. None of this worked because he has that gateway mutation. Was not a candidate for stem cells. He has been on Omacetaxine for over a year. The first round of 24 shots was way too much. He is now on six days of chemotherapy which is 12 shots. The problem is he goes from 40000 WBC to 200,000 in four days. The question is - Is there a way to adjust Omacetaxine to avoid this huge increase when it turns? Has anyone heard of another way of adjusting chemotherapy such as giving a small dose as soon as you see the turn at 40000? We are trying to avoid these horrific swings. Seems like as soon as it goes up, just a little, a small dose should be given until the next cycle. They are also fighting the low RBC so, he has to have transfusions periodically.
Kindly help.
Hello,
Welcome to icliniq.com.
I understand your concern. Treatment of CML (chronic myeloid leukemia) depends upon the patient's clinical condition and phase of CML. Usually, patients are given Imatinib or Nilotinib-like tyrosine kinase inhibitors drugs as a first line. But in this case, there is resistance to these drugs.
Omacetaxine and another group of drugs are used in patients having resistance to these drugs. So he has been prescribed Omacetaxine drug infusion. Follow the dosage of that drug in cycles as prescribed by your oncologist. It is not given alternatively and in small doses as per need. Follow the schedule of shots in cycles as prescribed by your oncologist.
I hope this has helped you. Thank you.
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Pathology
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