HomeAnswersObstetrics and Gynecologypapp-aWhat does PAPP-A screen test of 1.9 and hCG level of 65.6 indicate?

PAPP-A screen test result is 1.9 and hCG level is 65.6. What does it indicate?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Sameer Kumar

Medically reviewed by

iCliniq medical review team

Published At April 1, 2016
Reviewed AtFebruary 1, 2024

Patient's Query

Hi doctor,

My wife has done a PAPP-A screen test and results are 1.9 and hCG level 65.6. She is 12 weeks pregnant. Please advise regarding the same. Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome to icliniq.com.

You need to attach the complete report issued by the laboratory. Important thing is the graph and the MoM (multiple of the median) values which have been calculated as per the gestational age. The risk is calculated accordingly. In case of Down's syndrome, there is low PAPP-A (pregnancy-associated plasma protein A) levels and high hCG (human chorionic gonadotropin) levels which is what it looks like with the information provided. So please upload the scanned report completely for better review.

Patient's Query

Hi doctor,

I have attached the files for your reference. Please have a look.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

As suspected there is a high risk for trisomy 21 or Down's syndrome in the fetus as per the reports (attachments removed to protect patient identity). Next best way to confirm or rule it out would be to perform karyotyping of fetal cells obtained through amniocentesis procedure by 13-15 weeks of gestation. So, please opt for it and if the karyotyping by FISH (fluorescence in situ hybridization) indicates trisomy then it shall confirm that the fetus is Down's syndrome and then the decision shall be yours to continue or terminate before 20 weeks.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Sameer Kumar
Dr. Sameer Kumar

Obstetrics and Gynecology

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