Q. Can you list the drugs incompatible with Quetiapine and Lamotrigine?

Answered by
Dr. Bharat Udey
and medically reviewed by Dr. Sneha Kannan
This is a premium question & answer published on Feb 08, 2016 and last reviewed on: Apr 16, 2019

Hi doctor,

My query is regarding the incompatibility of Quetiapine and Lamotrigine with other groups of drugs. Now I have to get treatment for an anaerobic infection. I was prescribed Azithromycin, Clindamycin, Metronidazole and Mycomax. However, I will be extremely grateful if you list me all groups of drugs incompatible with Quetiapine and Lamotrigine or just list the most important ones. Thank you.



Welcome to

As such for Lamotrigine following drug interactions need to be considered as important.

  1. Valproate increases plasma level of Lamotrigine, hence dose need to be decreased if given with Valproate. Also there are increased chances of rash if given with Valproate.
  2. Antiepileptics such as Carbamazepine, Phenobarbital, Phenytoin, Primidone decreases plasma level of Lamotrigine, hence dose needs to be increased.
  3. Oral contraceptives also decrease plasma levels.
  4. No other important pharmacokinetic interactions.

For Quetiapine, Cytochrome P450 (CYP450) enzyme inhibitors reduces clearance of Quetiapine hence raises Quetiapine levels, therefore dosage needs to be reduced. May increase effect of antihypertensive agents. Besides these interactions no other major interactions with any other group of drugs.

Thank you doctor,

My psychiatrist told me that drugs prescribed by psychiatrist are primarily incompatible with one group of drugs. If so, can you name them?



Welcome back to

As such Lamotrigine have no major drug interaction with the drugs mentioned by you. So, it can be given along with them. Regarding Quetiapine, no major interactions noted with above mentioned drugs.

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