Does Duffy positive antigen and G0Po mean that women is pregnant or had a miscarriage?

Question

Hi doctor,

Are Duffy positive antigen Fy(a-b+) phenotype and Fy(a-b+) weak phenotype same? Is Fy(a-b+) caused by pregnancy? Do gynecologists or general physicians believe that Fy(a-b+) is caused by pregnancy? Does the obstetric history of G0Po mean the woman is both nulliparous and nulligravida, indicating that she might have had miscarriage abortion or induced abortion or stillbirth, or a non-viable pregnancy? Does it mean she has been pregnant in the past?

Please guide me.

Answer 1

Hello,

Welcome to icliniq.com.

The Duffy antigen is expressed on the red blood cells of the person in response to inflammation. There are different phenotypes,

1) a+b+.

2) a+b-.

3) a-b+.

4) a-b-.

The first three phenotypes are present in the Caucasian and Asian populations, and the fourth is present in the African American population. Fy(a-b+ weak) is when the allele expressing is weak. Hence these two are different. Change of phenotype to weak can occur in pregnancy, though incompatibility in Duffy phenotype can lead to hemolytic disease of newborn, which can cause pregnancy loss. Also G0Po mean nulligravida and nullipara. That means there has been no miscarriage, induced abortion, no viable pregnancy, or stillborn. It means that the woman has never become pregnant.

I hope this was helpful. Feel free to ask further doubts.

Does Duffy positive antigen and G0Po mean that women is pregnant or had a miscarriage?

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