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Why do I have recurrent fever with high CRP and ESR?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

For the past seven days, I have had a fever, headache, and body weakness. In the middle of the two days, there was no fever, but there was weakness. But tomorrow the fever comes again. I had some tests yesterday, such as CBC, dengue, and CRP. Dengue is negative, ESR 35, and CRP 48 mg/l.

Please help. Thank you.

Answered by Dr. Ashraf Ghani

Education:

MD

Professional Bio:

Dr. Ashraf Ghani is a dedicated general medicine physician committed to providing comprehensive and evidence-based healthcare for adult patients. He has experience in diagnosing and managing a wide range of acute and chronic medical conditions, including diabetes, hypertension, infections, respiratory illnesses, and lifestyle-related disorders. Dr. Ashraf Ghani focuses on accurate diagnosis, preventive care, and personalized treatment plans tailored to each patient's needs. Known for his compassionate and patient-centered approach, Dr. Ashraf Ghani strives to help patients achieve better health through clear communication and quality medical care.  

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome to icliniq.com.

I have gone through your query and understand your concern.

Based on your query, you have a persistent fever, headache, and body weakness, especially when your initial test results have not identified a clear cause.

The pattern you describe, a fever that comes and goes, may suggest an infection (viral or bacterial) rather than dengue. Other possibilities include malaria, typhoid fever, or systemic infections, depending on your local exposure risks.

Your complete blood count (CBC) and C-reactive protein (CRP) levels indicate inflammation, meaning your body is actively fighting an infection. The normal dengue test result is reassuring, suggesting that dengue fever is unlikely.

It is important to follow up with your doctor promptly for further evaluation, which may include:

  • Additional blood tests (for malaria, typhoid, or other infections).

  • Urine analysis (to rule out urinary infections).

  • Chest X-ray or ultrasound if indicated, to identify hidden sources of infection.

In the meantime:

  • Stay well hydrated by drinking plenty of fluids.

  • Take adequate rest.

  • Monitor your temperature and symptoms regularly.

  • Seek immediate medical attention if you develop high-grade fever, severe headache, shortness of breath, persistent vomiting, or confusion.

With timely medical care and proper investigation, the cause can be identified, and treatment can be started to help you recover safely.

I hope this helps you.

Thank you.

Medically reviewed by iCliniq medical review team
Published At December 28, 2025
Reviewed At December 28, 2025

Education:

MD

Professional Bio:

Dr. Ashraf Ghani is a dedicated general medicine physician committed to providing comprehensive and evidence-based healthcare for adult patients. He has experience in diagnosing and managing a wide range of acute and chronic medical conditions, including diabetes, hypertension, infections, respiratory illnesses, and lifestyle-related disorders. Dr. Ashraf Ghani focuses on accurate diagnosis, preventive care, and personalized treatment plans tailored to each patient's needs. Known for his compassionate and patient-centered approach, Dr. Ashraf Ghani strives to help patients achieve better health through clear communication and quality medical care.  

This doctor is not available for online consultations on the platform anymore.

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Education:

MD

Professional Bio:

Dr. Ashraf Ghani is a dedicated general medicine physician committed to providing comprehensive and evidence-based healthcare for adult patients. He has experience in diagnosing and managing a wide range of acute and chronic medical conditions, including diabetes, hypertension, infections, respiratory illnesses, and lifestyle-related disorders. Dr. Ashraf Ghani focuses on accurate diagnosis, preventive care, and personalized treatment plans tailored to each patient's needs. Known for his compassionate and patient-centered approach, Dr. Ashraf Ghani strives to help patients achieve better health through clear communication and quality medical care.  

This doctor is not available for online consultations on the platform anymore.

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