Can I achieve skin brightening by using vitamin C and Glutathione intravenously?

Q. Does taking vitamin C injections along with Glutathione cause any harm to the body?

Answered by
Dr. Dhepe Snehal Madhav
and medically reviewed by Dr. K Shobana
This is a premium question & answer published on Jan 23, 2021 and last reviewed on: Aug 30, 2023

Hi doctor,

Does taking vitamin C injections with Glutathione weekly cause any harm? I went to a dermatology clinic and the personnel told me that there are no adverse side effects other than urine discoloration while using it. To get good results, they recommend taking both Glutathione and vitamin C intravenously for six weeks and it has to be followed every two weeks. But some sources criticize intravenous use of Glutathione and its adverse effects. Some dermatologist warns people against taking Glutathione intravenously.



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Please mention whether you have a liver issue or renal issue, have a dull skin tone, and a history of skin aging. You have not attached a picture of the condition. Kindly attach a picture of the affected area to help you better. I need to see the affected area to assess the condition and to provide an appropriate diagnosis and treatment. Glutathione is an antioxidant produced by the body. It helps to reduce skin aging, stress and acts as a skin lightening agent. There are many products that are currently available as over the counter such as Hydroquinone, Vitamin C serum, Vitamin E, Niacinamide, Glycolic acid, and Kojic acid.

Thank you doctor,

I have dull skin and I want to achieve a bright looking skin. I saw some sources that Glutathione and vitamin C injections result in skin brightening effect. Now, I want to know the risks of using it. The personnel told me that there are nine treatments to be followed to have vitamin C and glutathione injections and it should be done weekly. The remaining injections should be taken every two weeks. They told me that there are no side effects. I want to know the risks of using Glutathione and vitamin C treatment.



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These products have variable effects from person to person. But Glutathione has become popular due to its fastest skin lightening action and also due to wide social media coverage. Glutathione is a peptide derived from three amino acids such as glutamate, cysteine, and glycine. It is known as an antioxidant and detoxifies xenobiotics. Tyrosinase is an enzyme and it helps in melanin synthesis. Melanin is a pigment that decides the color of skin. When you have more melanin and so you have darker skin. Glutathione inhibits this enzyme and so melanin is produced in reduced quantity resulting in skin lightening. Natural sources like tomato, oranges, walnuts, whey protein, fresh fruits, and green leafy vegetables are rich in glutathione. Various formulations like topical, oral, and injectable forms are available.

Thank you doctor,

What are the risks of injectables?



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The intravenous dose recommended is 600 to 1200 mg once or twice a week. There are various adverse effects observed in the intravenous route due to overdose toxicities or due to additives present in the glutathione injections. IV (intravenous) Glutathione can cause various adverse effects. It can cause thyroid dysfunction, kidney dysfunction, and severe abdominal pain. Due to its long term usage, light-colored patches can appear on the body and peptic ulcers can occur. You can use Ahaglow face wash (Aloe vera extract, Glycolic acid, and vitamin E) twice daily to wash your face for a month. It helps to reduce fine lines. It exfoliates dull skin and improves skin tone. You can take tablet Limcee 500 mg (Vitamin C) once a day after breakfast for two months. You can use Photostable sunscreen at 9 o'clock in the morning, 12 o'clock in the afternoon, and at 3 o'clock for two months even indoors. Avoid going out under direct sun. Apply sunscreen half an hour before going outdoors. Vitamin C serum can be used as night cream and after half an hour of its application, you can use a moisturizer like Cetaphil or Venusia that suits your skin. You can use Kojic soap for bathing for a month. If you have hyperpigmentation, you can use Kojic cream (Kojic acid with Lactokine fluid) for six weeks at night. Your skin can look dull due to the presence of dead skin cells on the face. These above-mentioned treatments will help to make your skin to glow.

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