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Q. How can motor and sensory nerve weakness be managed in an AIDP patient?

Answered by
Dr. Hitesh Kumar
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jul 05, 2019

Hello doctor,

My hands and legs are very weak for the past two years. The doctor diagnosed that I have AIDP or Guillian-barre syndrome. He gave me some medicines such as Methylcobalamin and other supplements and in the acute 12 IV injections of Cobalamin and I am recovering but I think very slowly. So please tell what is the best thing I should do. My MRI was clean. Thyroid, sugar, and calcium were normal. NCV showed motor weakness, sensory weakness. I do not have any kind of pain.

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Hello,

Welcome to icliniq.com.

AIDP or GBS is an autoimmune disease. Which can be primary or also can be secondary other autoimmune diseases. As you are telling that you are recovering, it is a good thing. There is no medicine for rapid recovery after six months. Only medication available is for stopping the progression of weakness in the acute stage (IV Ig or Plasmapheresis). At this stage, you need regular physiotherapy and it takes a few weeks to a few months for recovery. Few patients do not have a complete recovery. Also, you should get further test for detecting any secondary autoimmune disease ANA, C-ANCA, P-ANCA, serum ACE level. Sometimes, chronic demyelinating neuropathy can present as acute presentation. For that need to see NCV graphs and if suspected, may need nerve biopsy.


Investigations to be done:

1.NCV all four limbs (to be reviewed).
2.ANA, C-ANCA, P-ANCA, serum ACE levels.
3.Sural nerve biopsy.
4.CSF examination to look for albuminocytological dissociation.

Differential diagnosis:

1.AIDP (acute inflammatory demyelinating polyradiculoneuropathy).
2.Acute presentation of CIDP.


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