HomeAnswersHematologyhigh lymphocyte countWhat does chronically elevated lymphocytes count mean?

Why am I having elevated lymphocytes?

Share

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Divya Banu M

Published At May 28, 2019
Reviewed AtOctober 30, 2023

Patient's Query

Hello doctor,

For the past five years, my absolute lymphocytes have been 4.2 to 4.9 range, never going over 5 (I have had multiple CBC and every single one of my absolute lymphocytes is elevated). However, they have been continually elevated to the point that I was recently sent to a hematologist who initially thought I had CLL, but the flow cytometry test came back negative, then he did a T-cell gamma rearrangement test, which also came negative. At that point, he decided it must be autoimmune and sent me back to my PCP.

Several years earlier when all this started, I woke up with joint pain, and swelling and was sent to a Rheumatologist who decided I had RA despite every RA test being negative, and the joint swelling not following what is clinically seen in RA (my joints were not bilaterally swollen, red, or hot. They were randomly swelling in my hands, feet and were really painful). So, I refused to take Methotrexate because I had no positive RA tests, and after about a year, the swelling went down, the pain faded away and I have had no other flares since that time.

So, my question is, should I try to get to the bottom of my chronically elevated absolute lymphocyte and if so, are there any other tests I should have my PCP pursue? I do not want to blame it on the RA when there is no proof I ever had RA but at this point, five years of elevated absolute lymphocytes are concerning to me and I feel like it is indicative of something, but I do not know what.

Hello,

Welcome to icliniq.com.

If you have any type of leukemia especially CLL (chronic lymphocytic leukemia) or MBL (monoclonal B-cell lymphocytosis) then it could have been reflected in the peripheral smear examination report or in flow cytometry investigation. Your flow cytometry report is negative and hence it suggestive of non-leukemia condition. Autoimmune disease chances can be there. So for that, you need to investigate with serum ANA estimation, ESR estimation and then if needed full autoimmune cell panel can be run to exclude any possibility of autoimmune disorder. If you have chronic cold symptoms then also it can be causative for high lymphocytes.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Goswami Parth Rajendragiri
Dr. Goswami Parth Rajendragiri

Pathology

Community Banner Mobile
By subscribing, I agree to iCliniq's Terms & Privacy Policy.

Ask your health query to a doctor online

Hematology

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.

This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy