Percentage of B cells is high. Is it leukemia?

Question

Hello doctor,

Here are my immunohistochemical results of peripheral blood:

Absolute lymphocyte count 5812/uL reference (1000 to 3300) with CD19 (B cells) 62 percent reference (3 to 20 percent), CD45 positive, CD10 positive, and CD5 negative.

How do we know if it is leukemia or not?

Doctors in our town cannot interpret the result. The percentage of B cells is highly abnormal.

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

At the age of 55 years, if persistent lymphocytosis is seen, then CLL (chronic lymphocytic leukemia) should be ruled out. For that, monoclonality should be confirmed by flow cytometry investigation and requires a bone marrow study apart from a peripheral smear examination report if needed.

In CLL, usually, the peripheral smear examination report shows smudge cells and more than 90 percent lymphocytes. So, provide a peripheral smear examination report, a bone marrow aspiration study report, and a flow cytometry report if available.

The mentioned markers are of B cells, but CD5 is negative, so further workup is needed, as mentioned.

I hope this will help you.

Thank you.