Q. Percentage of B cells is high. Is it leukemia?

Answered by
Dr. Parth R Goswami
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jan 27, 2018

Hello doctor,

Here are my immunohistochemical results of peripheral blood: Absolute lymphocyte count 5812/uL reference (1000-3300) with CD19 (B cells) 62% reference (3-20%), CD45 positive, CD10 positive, and CD5 negative. How do we know it is leukemia or not? Doctors in our town cannot interpret the result. The percent of B cells is high. Abnormal. Please help.

#

Hello,

Welcome to icliniq.com.

At the age 55 years, if persistent lymphocytosis is seen, then CLL (chronic lymphocytic leukemia) should be ruled out. For that, monoclonality should be confirmed by flow cytometry investigation and need bone marrow study apart from peripheral smear examination report if needed.

In CLL usually, peripheral smear examination report shows smudge cells and more than 90 % lymphocytes. So, provide peripheral smear examination report and bone marrow aspiration study report and flow cytometry report if available.

The mentioned markers are of B cells but CD5 is negative, so further workup is needed as mentioned.

Hope this will help you.

For more information consult a hematologist online --> https://www.icliniq.com/ask-a-doctor-online/hematologist


Was this answer helpful?

 | 

Same symptoms doesn’t mean you have the same problem. Consult a doctor now!



Related Questions:
Ferritin level has decreased in spite of taking iron supplements. Should I worry?

Is it why my levels got high ... My thrombocyte levels got higher again, unfortunately ... Another thing I am worried about is, my lymphocytes kind of got increased in my blood: (528) - the reference is 194 to 449, and the ot...   Read full

Percentage of B cells is high. Is it leukemia?

.. age 55 years, if persistent lymphocytosis is seen, then CLL (chronic lymphocytic leukemia) should be ruled out. For that, monoclonality should be confirmed by flow cytometry investigation and need bone marrow study apart from peripheral smear exam...   Read full

I had viral fever and my blood report shows lymphocytosis. What is the cause for elevation?

In CLL, the lymphocytosis is much high but in your case it is borderline ... What can cause this relative elevation in lymphocytes ... The lymphocytes are slightly elevated ... As you can see, although my overall WBC ...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read


Tomato Fever - Causes, Symptoms, Diagnosis, Treatment, and Prevention
Tomato fever is an unidentified and fast-spreading type of viral infection seen in young children. Scroll down to know m...  Read more»
Histrionic Personality Disorder - Causes, Signs, Symptoms, Diagnosis and Treatment
Histrionic personality disorder causes variations in the thinking ability of a person. Read this article to know more.  Read more»
Nighttime Skin Routine for Clear Skin
A skin that gets all the attention during the day requires a chance to repair, rejuvenate and replenish from day damage ...  Read more»

Ask your health query to a doctor online?

Ask a Hematologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.