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When is the best time to get HSV IgG done to get the conclusive and accurate results?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Nagaraj

Medically reviewed by

Dr. Chithranjali Ravichandran

Published At April 15, 2021
Reviewed AtApril 15, 2021

Patient's Query

Hello doctor,

Which herpes test to get done after possible unprotected exposure, HSV IgM or HSV IgG?

And when is the best time to get HSV IgG done or after how many weeks to get the conclusive and accurate result?

Answered by Dr. Nagaraj

Hello,

Welcome to icliniq.com.

I understand your concern. For genital or oral herpes infection, the incubation period is around two weeks. It means it takes an average of 12 to 14 days to develop symptoms after exposure. You can get it done around two weeks after exposure. This is regardless of symptoms. If you have any symptoms like a sore around the mouth or private parts if there is discharge or painful urination, get the test done now.

IgM antibodies are produced immediately after infection, and after few weeks, these antibodies are replaced by IgG.

If someone already had HSV in the past, IgG will be positive for a lifetime. In such cases, PCR for HSV virus detection will be the best. In any case, consult your doctor for further information. I hope this helps.

Take care.

If you are satisfied with my response, kindly provide your feedback.

Thanks.

Patient's Query

Hi doctor,

I had swelling on my foreskin and glans with a discharge under the foreskin with painful urination, and this started after three days of exposure. And the doctor gave me Flucanozole, Doxycycline, and antivirals. After a month, it got better, and I went for a lab test for HSV IgM and IgG, chlamydia, RPR, HIV. All these tests came back negative, but only my HSV IgM was positive with a 1.66 index. But then I asked my partner to get tested after 40 days of our intercourse. And she had positive chlamydia IgA with 1.71 indexes and IgG with 1.08 index, her HSV IgG was positive with 1.66 indexes, and all her other test RPR, HIV came back negative. And I tested myself for HSV IgG again after 42 days from my first test, which is now ten weeks after infection, and it came back negative as my earlier test. So I want to know whether I had a bacterial infection or herpes? And is the HSV IgG test conclusive after ten weeks? Because my HSV IgG is still negative even after ten weeks after my infection, and why my HSV IgM was positive?

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

Chlamydia infection is more common in females than in males. Many times they are silent carriers. It means they may not have any signs or symptoms but still can transmit infection. Your testing positive for HSV-specific IgM confirms the same. However, you have not yet developed IgG antibodies yet. But they will develop in due course. The course can be variable and depends on the person's immune status. Coming to your specific questions, it looks like you had HSV. IgG antibodies will develop in due course, and they will remain positive thereafter. Your HSV IgM was positive as you had an HSV infection. It looks like your partner has or had a Chlamydia infection. She could be a silent carrier. Note that it is treatable and ask her to consult a doctor for the treatment.

I hope this helps.

Take care.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Nagaraj
Dr. Nagaraj

Diabetology

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