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Why does a person experience hypoglycemic episodes after the laparoscopic removal of acute perforated appendicitis?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I am a 56 year old female who starting having hypoglycemic episodes after the laparoscopy removal of an acute perforated appendicitis. I was treated with heavy doses of antibiotics and had to wait six weeks before the inflammation went down to get my appendix removed. I recently consulted an endocrinologist, who determined that my amylase and c-peptide levels are elevated. My amalyse was 192 following the two glucose tolerance tests, the c peptide was low at 1.0, then increased on the second test at 10.2, but my glucose was normal.

I have been referred to gastroenterology to investigate if there might have been a surgical issue but have not met with them. In the meantime, I am monitoring my glucose levels and have cut back on exercise and sticking to my whole food plant based diet. Please advise.

Answered by Dr. K. Shanmuganandan

Education:

MBBS

Professional Bio:

Dr. K. Shanmuganandan is a dedicated General Practitioner with specialization in Rheumatology. He offers comprehensive medical care while focusing on the diagnosis and management of joint, muscle, and autoimmune disorders. With a patient-first approach, he combines preventive care, accurate treatment, and health education to improve quality of life.His areas of expertise include rheumatic diseases, arthritis management, and autoimmune condition care.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome to icliniq.com.

Thank you for your query,

Your high amylase and c peptide levels are due to perforated appendix, since your glucose levels are normal. However, I would like to ask few queries for better understanding of illness

  1. What is your hemoglobin A1C levels?
  2. How is your appetite and is there any weight loss?
  3. Was your hypoglycemia documented?
  4. Did you have any electrolyte changes?

Thank you.

Medically reviewed by iCliniq medical review team
Published At June 2, 2023
Reviewed At May 8, 2026

Education:

MBBS

Professional Bio:

Dr. K. Shanmuganandan is a dedicated General Practitioner with specialization in Rheumatology. He offers comprehensive medical care while focusing on the diagnosis and management of joint, muscle, and autoimmune disorders. With a patient-first approach, he combines preventive care, accurate treatment, and health education to improve quality of life.His areas of expertise include rheumatic diseases, arthritis management, and autoimmune condition care.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. K. Shanmuganandan is a dedicated General Practitioner with specialization in Rheumatology. He offers comprehensive medical care while focusing on the diagnosis and management of joint, muscle, and autoimmune disorders. With a patient-first approach, he combines preventive care, accurate treatment, and health education to improve quality of life.His areas of expertise include rheumatic diseases, arthritis management, and autoimmune condition care.

This doctor is not available for online consultations on the platform anymore.

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