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HomeAnswersHematologyjoint painWhat is the cause for worsening muscle and joint pain for a longer period?

What causes muscle and joint pain without any relief?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At November 23, 2019
Reviewed AtJune 4, 2024

Patient's Query

Hello doctor,

I am experiencing muscle pain and joint pain for ten years which consistently got worse. The recent diagnosis shows leukocytosis. My WBC is consistently high at around 13000 to 15000. I also suffer fibromyalgia, migraines, TIA, unknown source of seizures, peripheral neuropathy, left hemiparesis, muscle disorder, muscle spasm-paresthesia, diabetic type 2, AVN of hips, DDJ and DDD disease.

I am currently taking Bacoflen 20 mg four times a day, Cymbalta 30 mg once daily, Valium 5 mg, Gabapentin 300 mg four times a day, Humalog, Metformin 1000 two times a day, Bydureon Pen once a week, and Medical Cannabis. I consulted a rheumatologist and a neurologist. Rheumatologist swore it was Lupus. The neurologist swore it was SPS.

My recent laboratory report:

1. Complement component C3C - 188H Range 90-180 (twice tested).

2. Glucose 168 mg/dL.

3. Alpha 1 globulin 4H - Range 0.2 - 0.3.

4. Gamma globulin 7L - Range 0.8 - 1.7.

5. Vitamin D - 18L - Range 30 - 100.

6. C-reactive protein 0.83H.


Welcome to icliniq.com. Your main presentation is chronic muscle pain and joint pain. For that specific cause rule out first like connective tissue disorder, muscle dystrophy, neuropathic pain, spinal problem, HIV, thyroid issue, etc.

For connective tissue panel testing, CT scan, serum TSH (thyroid-stimulating hormone) estimation, serum T4 estimation like investigations are useful. Here neurologist may perform investigation like NCV (nerve conduction velocity), EMG (electromyography), for finding the specific cause. According to the cause further specific treatment will be given. If SLE (systemic lupus erythematosus) suspected by rheumatologist then it will be confirmed by connective tissue panel testing that includes testing of anti-dsDNA, anti-Sm, etc. You are prescribed Gabapentine, muscle relaxant and Duloxetine drugs and these drugs can cause fibromyalgia or chronic fatigue syndrome. Control your diabetes as it can lead to neuropathic pain and other complications. As per report vitamin D looks out of range that is low, so for that Cholecalciferol sachet can be taken with milk once a week.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Goswami Parth Rajendragiri
Dr. Goswami Parth Rajendragiri


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