Dr. Karthik Rajan
Urology
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Patient's Query
Hello doctor,
Can a slight reduction in blood supply and poor blood circulation in both testes increase the risk of de novo single gene mutation present in a normal motile sperm? Will fertilization of this type of sperm result in a child with de novo single gene disorder with the sole reason being lesser oxygen, nutrients, and hormones being supplied to the testes?
Hello,
Welcome to icliniq.com.
What you have mentioned is correct.
However, since the paternal DNA (deoxyribonucleic acid) is normal, the mutation will be affecting a single sperm or those derived from a single germ cell in the case of single gene mutations. It is impossible to know whether the genetic mutation has any functional significance. The scenario you mentioned is entirely possible but given the number of sperms in the ejaculate, the probability of such an event is low.
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Urology
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