Q. There is a drastic decrease in my platelet count in the last five months. Why?

Answered by
Dr. Goswami Parth Rajendragiri
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 06, 2017 and last reviewed on: Jun 09, 2023

Hi doctor,

My hemoglobin level increased from 15 to 17, and platelet count decreased from 3.1 to 1.4*10^3 per microliter of blood in the last five months. The only symptom I have is occasional skin itching.



Welcome to

  1. As your platelet count decreased over four months duration, chronic infection, and drug history have to be ruled out first.
  2. If they are not causative then a detailed investigation plan should be decided according to the examinations as follows:
    1. ESR (erythrocyte sedimentation rate) or CRP (C-reactive protein).
    2. Blood culture.
    3. Alcohol history.
    4. Peripheral smear examination.
    5. Renal profiles such as uremia might lead to decreased platelet count.

Your hematocrit should be checked. If it is high and RBC (red blood cell) mass is elevated with persistently elevated hemoglobin over 18, then the JAK2 mutation has to be tested to rule out the myeloproliferative disorder. According to the cause, further specific treatment will be given. Hence, first, consult your physician for examination and get your liver and spleen examined by the doctor. Then, get a proper workup planned according to the need.

Take care.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Can multiple myeloma be misdiagnosed over chronic alcoholism?

.. can strongly suggest myeloma; however, marrow biopsy is needed. But, one can fairly be sure about the diagnosis. Before starting treatment one will need the bone marrow biopsy. Also, bony lesion if visible on x-ray, then one may proceed without MR...   Read full

Should I worry about low platelet count with fever if dengue test is negative?

Hi doctor, My son is five years old, and he was suffering from fever, headache and body pain ... His fever was ranging from 101 to 1025 degrees ...   Read full

Is there any medicine to overcome the effects of alcohol?

.. now acknowledged as a disease that requires a combined treatment (medications, psychological and social intervention). Medications to increase tolerance of the patient to alcohol as Iomazenil are not very much recommended as they tend to increase...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

Coronavirus Variant Arcturus: | Omicron XBB.1.16 Variant
Arcturus is an emerging variant of the Omicron virus that causes various symptoms and spreads rapidly across the world. ...  Read more»
Adrenaline Rush - Symptoms, Causes, Effects, and How to Control
Adrenaline is a hormone responsible for fight or flight response. It is also a neurotransmitter and medicine. It is also...  Read more»
Fatty Liver - Types, Symptoms, Stages, and Treatment
The liver is the largest gland in the body. Its primary function is to process the food and drinks we consume. and filte...  Read more»

Ask your health query to a doctor online?

Ask a Hematologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.