HomeAnswersObstetrics and GynecologymchI have high MCH and low RBC. Can it be neural tube defects?

Can elevated MCH and decreased RBC levels result in neural tube defects in a 5-week pregnant woman?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At January 15, 2023
Reviewed AtOctober 10, 2023

Patient's Query

Hi doctor,

I have just received my prenatal blood test results and am very concerned about it. I am five weeks pregnant, and my results show my MCH is 35.1 g/dL and my RBC is 3.85 million cells/mcL. I redid my blood tests today, and they gave me access to the results. I am extremely concerned about my RBC (3.85 million calls/mcL) and MCH (35.1 g/dL) levels and am confused since I have been taking prenatal vitamins for a long time. Are these numbers very concerning? Does that mean I have not had enough vitamin B12 and folic acid? Could there be a neural tube defect? Is there something I can do now? I am taking the Materna prenatal vitamins, but I am worried now. I have a son, and I never had this issue before.

Please help.

Hi,

Welcome to icliniq.com.

I went through the query and understood your concern.

MCH (mean corpuscular hemoglobin) is the average quantity of hemoglobin in a single red blood cell. Your MCH value is slightly increased, but it is reassuring that your other indices, like MCV (mean corpuscular volume) and MCHC (mean corpuscular hemoglobin concentration), are normal (attachment removed to protect the patient's identity). Also, your hemoglobin values are within the normal range. So do not worry. It is unlikely that to have folate or vitamin B12 deficiency to the extent that it will lead to neural tube defects.

I suggest you increase the intake of green vegetables, lean meat, and eggs in your diet. Continue taking your prenatal vitamins (check for folate amounts in your tablets- it should be at least 400 micrograms). And do not stress yourself. You will be fine.

I hope I have answered your questions.

Kindly feel free to reach out for further questions.

Patient's Query

Hi doctor,

Thank you for your quick response. I really appreciate it.

My prenatal vitamins consist of folate 600 mcg; should I add an additional folate pill? Do these results show I am missing folate or vitamin B12 supplements? Is the value of MCH 35.1 g/dL very high? As I am five weeks pregnant, I am worried that I will not have enough folate once the neural tube closes next week, and there might be an issue. If I was not absorbing enough folate until such an early point in the pregnancy, could there be a problem?

Please answer.

Thank you.

Hi,

Welcome back to icliniq.com.

As your prenatal vitamins have 600 mcg of folate, you do not need an extra pill. The levels of MCH 35.1 g/dL are not very high at all. If there were a folate or vitamin B12 deficiency, your MCV (mean corpuscular volume) index would have been altered (which has not occurred in your case). So do not worry. If other indices are normal, we do not expect any neural tubal defects with MCH levels at 35 g/dL. And regarding the malabsorption of vitamin B12 or folate, are you experiencing any pins and needles-like sensations in your hands or feet? Do you have mouth ulcers, smooth tongue, nausea, or vomiting?

If you have the above symptoms, I suggest you check your serum vitamin B12 levels.

I hope this has helped you.

Take care.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Priyadarshini Tripathy
Dr. Priyadarshini Tripathy

Obstetrics and Gynecology

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