How to manage burning palms and feet in an anemic person?

Question

Hello doctor,

I have megaloblastic anemia, but no intrinsic factor deficiency, and have been diagnosed for nine years. I have taken CBC and intrinsic factor tests. My current medication is Methylcobalamin.

I have an MTHFR gene mutation in both alleles, but I am largely unresponsive to my weekly 1000 MCG injections. My symptoms, like burning palms and feet, memory loss, and depression, keep getting worse. What should my next step be?

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

Thank you for your query.

You have an MTHFR (methylenetetrahydrofolate reductase) gene mutation, so your metabolism of homocysteine can be affected. Homocysteine can be elevated in such a mutation. So check your homocysteine level because a high level of it is associated with cardiovascular disease problems.
Check your vitamin B12 level after methylcobalamin injections; your B12 level might have improved.
For your burning palm symptoms, check your thyroid and sugar status as well.
Kindly mention your blood pressure value and smoking history, if present.
What was your vitamin B12 value before the injection?

I hope this has helped you.

Kindly revert in case of further queries.

Thank you.