Can depression and anxiety cause bowel problems?

Hi doctor,

I am a 39-year-old man with ADHD, depression, generalized anxiety disorder, and panic disorder with agoraphobia for the past 20 years. I also have irritable bowel syndrome, which worsens my agoraphobia. I get nightmares like my car breaking down and becoming incontinent with my bowels. I am terrified of becoming incontinent in public, making me stay indoors. I am helpless and entirely housebound now due to my suicidal thoughts. I am currently taking Pregabalin, Mirtazapine, Escitalopram, Propranolol, Quetiapine, and Diazepam occasionally. I cannot work due to my agoraphobia, and I consulted psychologists and counselors and underwent therapies like CBT, ACT, NLP, and hypnotherapy. I have also tried SSRIs, tricyclic antidepressants, anti-psychotics, and nasal Esketamine. Unfortunately, these treatments did not help me. I have read every book on agoraphobia and tried my best to overcome my depression, resulting in maladaptive defensive behavior. I did try Methylphenidate, but the side effects were severe. One drug that helped the depression was Aripiprazole, but I could not sleep due to panic attacks. What should I do for my mental health? Please help.

Thank you doctor for the reply,

Could you explain in detail the different class of drugs? I am currently taking Pregabalin 300 mg twice daily, Quetiapine 150 mg, Mirtazapine 30 mg, Escitalopram 20 mg, Propranolol 40 mg thrice daily, and Diazepam as and when required. Please help.