Can regular intake of Methotrexate affect the fetus?

Question

Hello doctor,

I am approximately four weeks pregnant based on the date of conception. I have rheumatoid arthritis and take Methotrexate 10 mg a week, along with Folic acid 10 mg. I stopped taking Methotrexate as soon as I found out about the pregnancy, which was one week ago. So, since conception, I took Methotrexate twice before discovering the pregnancy. Now, I am debating between termination or carrying the pregnancy to term. I am aware that it is strongly advised not to take Methotrexate during pregnancy or even shortly before conception. I am uncertain about what to do, and I am seeking medical advice to make an informed decision. My rheumatologist is undecided and unable to provide further guidance.

Please help. Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I have read your query, and I can understand your concern.

You do not need to worry about your exposure to Methotrexate during your four-week pregnancy. As long as it is not an overdose, I do not think it may affect your pregnancy. To be sure, please kindly undergo a fetal biophysical profile or fetal anomaly scan to evaluate for possible fetal abnormalities. You can continue with your Folic acid medication.

I hope this helps. Please schedule another appointment for follow-up via chat, phone, or video consultation.

Thank you for using icliniq, and have a nice day.