Q. Does opiate withdrawal cause nausea, low BP, muscle pain and urea smell?

Answered by
Dr. Aida Abaz Quka
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jun 08, 2018 and last reviewed on: Jan 27, 2023

Hello doctor,

I am a 40-year-old female recovering from eating disorder. My BMI is 16. I am suffering from clinical depression and GAD. I was diagnosed by a neurologist with migraines approximately two years ago, and have been on Lyrica 75 mg twice daily. Recently, I started having trouble swallowing (endoscope was normal), so I returned to the neurologist who prescribed Topamax 15 mg SC. I suddenly switched to Lyrica 75 mg in the morning, and Topamax 15 mg at night and developed the most insane premenstrual migraine I have ever experienced. I have never experienced that intensity of migraine symptoms, ever. I had shimmering or flickering vision, sometimes a white haze, parasthesia across forehead (with or without a slight headache), parasthesia down right side of body, upper back or neck muscle pain, irregular heartbeats, sudden whooshing sensation and feeling like I was going to faint accompanied by feeling of doom, confusion and mild hallucinations (almost like I was having a seizure), dizziness and nausea (especially with light and smells), dehydration (could not eat or drink because of nausea and swallowing issues), occasional twinging in chest. It got so bad that I got the family to drive me to the ER. By the time we arrived, I was unable to answer simple questions, and the attendor was concerned about TIA, so they admitted me, and I was seen by my neurologist, who ordered a CT scan. My results were blood count, platelet count, ESR, urea, creatinine, a lipogram, glucose fasting, TSH were normal except slightly low kidney function. ECG was normal (normal on the previous admission too, so were cardiac blood tests), chest X-ray, CT scan were normal, BP was consistently low (between 95-105 over 65-75 mmHg) lowest 88/45 mmHg while in hospital. The temperature was consistently normal.

Since being discharged, I have had nausea, dizziness, sweating, urea kind of smell through my back, extreme muscle pain, low blood pressure. I returned to my GP twice because I was concerned about these symptoms. It suddenly dawned on me that these opiate-like withdrawals could be due to me suddenly stopping all of my medications before admission, the Lyrica in particular. The more I read, the more concerned I get. I saw a study where a woman had gone cold-turkey on Lyrica and ended up with cerebral edema. I guess my question is, can I safely continue weathering these withdrawal symptoms? Would the CT have picked up edema and would there be a danger of it randomly happening now that I am a few days cold-turkey off Lyrica? I do trust professionals and do not like to self-diagnose, but my anxiety levels are through the roof, and I am now certain even the hospital visit was a result of the sudden drop in dosage and combination of Lyrica and Topamax. I would appreciate your input.



Welcome to

It is fine to stop Lyrica (Pregabalin). In my opinion, your symptoms could be related to a panic attack, probably caused by Topiramate adverse effects. Besides, as Topiramate can also cause kidney dysfunction. So, I strongly agree with your doctor on stopping it. On the other hand, Lyrica is not the best drug for migraine headaches prevention.

Brain edema is a serious medical condition, where the patient is usually drowsy or unconscious, with possible seizures or coma. So, I do not think that there is any serious medical condition going on. Lyrica can help against anxiety and stopping Lyrica may lead to increased anxiety. Anyway, these withdrawal symptoms are quite transitory, and you have nothing to worry about. I would recommend discussing with your doctor on the possibility of starting Amitriptyline or Propranolol in low doses to help prevent migraine headaches. These two drugs can help also improve anxiety.

For more information consult a neurologist online -->

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