ADVERTISEMENT

Q. What is the treatment for paracetamol poisoning?

Answered by
Dr. Sadaf Mustafa
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Nov 28, 2016 and last reviewed on: Oct 09, 2018

Hi doctor,

My friend took 4 g of Paracetamol yesterday morning for back pain. Then, he visited the hospital yesterday evening for Paracetamol poisoning. What is the treatment for this situation?

ADVERTISEMENT
#

Hello,

Welcome to icliniq.com.

  • More than 3.5 g of Acetaminophen can cause liver toxicity. But, one time dose should not cause too much harm. Technically, if it is more than two to four days, then the accumulative effect is dangerous.
  • Since he went late, I doubt that he would have received the activated charcoal. The drug of choice is N-Acetylcysteine.
  • The treatment is aimed at removing the Acetaminophen from the circulation and replacing it by glutathione.
  • This antidote Acetylcysteine acts as a precursor for glutathione. It helps to prevent damage to the liver. N-acetylcysteine can neutralize NAPQI (N-Acetyl-p-benzoquinone imine) by itself, which is an active metabolite of Paracetamol causing the main damage.
  • There are protocols using N-Acetylcysteine that can be followed to help prevent progression of the disease, but it depends upon the hospital if they have adopted it or not.

For further doubts consult an internal medicine physician online --> https://www.icliniq.com/ask-a-doctor-online/internal-medicine-physician


Was this answer helpful?

 | 

Same symptoms doesn’t mean you have the same problem. Consult a doctor now!



Related Questions:
My left tonsil is swollen, and I have a severe post-nasal drip from a month. Please help.

In addition to those, to help remove excess mucus, I suggest Ambroxol or N-Acetyl cysteine twice daily ...   Read full

Will using Percoset cause any side-effects?

.. safe compared to Percoset. Single use of Percoset never causes permanent side effects. The side effect caused by a single dose (such as loss of appetite and difficulty in emptying bladder) will be for one day only. Once the amount of drug gets exc...   Read full

How can you tell the difference between food poisoning or possible Acetaminophen poisoning?

Hello doctor,I am asking about a 10-year-old girl. She is acting like she is much older than her age (in the wrong way). She is exhibiting behaviors of a 16-year-old, and it is very concerning. She is wearing heavy makeup, making lip-syncing videos u...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read


Monkeypox Virus - Symptoms, Diagnosis, Treatment, Complications, and Prevention
Monkeypox is a zoonotic viral disease. This virus got its name as it was first noticed in laboratory monkeys in the late...  Read more»
Tomato Fever - Causes, Symptoms, Diagnosis, Treatment, and Prevention
Tomato fever is an unidentified and fast-spreading type of viral infection seen in young children. Scroll down to know m...  Read more»
Histrionic Personality Disorder - Causes, Signs, Symptoms, Diagnosis and Treatment
Histrionic personality disorder causes variations in the thinking ability of a person. Read this article to know more.  Read more»

Ask your health query to a doctor online?

Ask an Internal Medicine Physician Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.