Can Cymbalta and Phentermine be used together for weight loss?
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Q. Can I take Phentermine along with Cymbalta?

Answered by
Dr. Srivastava, Sumit
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jun 07, 2016 and last reviewed on: Jul 07, 2023

Hi doctor,

I take Cymbalta 60 mg for depression and Trazodone 100 mg for sleep. Can I take Phentermine for weight loss without problems of serotonin syndrome?

#

Hi,

Welcome to iCliniq.com. Phentermine is a medication that is typically used for a short period of time, usually a few weeks, as an adjunctive treatment for weight reduction in patients with an initial body mass index (BMI) equal to or greater than 30 kg/m². Cymbalta, which contains the active ingredient duloxetine, has a serious interaction with Phentermine. When taken together, they can increase the toxicity of each other and pose a potential risk for serious or life-threatening interactions. Additionally, there is a risk of developing serotonin syndrome, which is a condition caused by excessive levels of serotonin in the body and can be life-threatening. Therefore, based on these interactions and risks, I would not recommend the simultaneous use of Cymbalta and Phentermine. Please let me know if you have any further questions or concerns.


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