Duloxetine is an antidepressant drug that belongs to the drug group selective serotonin and norepinephrine reuptake inhibitors (SSNRI). This drug is used to treat anxiety, depression, fibromyalgia, nerve pain associated with diabetes, and other chronic muscle pain. It is available in a capsule form, which has to be taken orally.

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How to prevent serotonin syndrome while taking antidepressants?

Query: Hi doctor, I am under treatment for OCD and anxiety symptoms. I have had very hard months with extreme anxiety, panic attacks and depersonalization. Now, I am on Duloxetine 60 mg (will stop in the next 7 weeks), Paroxetine 20 mg (will be reduced in the following weeks), Clomipramine hydrochloride...  Read Full »

Dr. Kumarshri Shriniwas Saraswat

Psychiatrist, Psychologist Counsellor, Psychotherapist, Sexologist, Sleep Medicine Physician

Answer: Hi, Welcome to icliniq.com. There is always a possibility of serotonin syndrome when two or more serotonergic antidepressants are being used. However, Clomipramine and an SSRI (selective serotonin reuptake inhibitor) like Paroxetine are frequently used together in resistant OCD (obsessive-compulsive...  Read Full »

How to manage sciatica pain?

Query: Hi doctor, My brother has been suffering from sciatica for a long while now. He gets flare-ups where he cannot move very much without being in pain. He tried massages from specialists and some cushions, but they do not seem to work very well. He is 26 years old but is stubborn to get help as he fe...  Read Full »

Dr. Atul Prakash

Fitness Expert, Orthopaedician And Traumatologist, Physiotherapist, Spine Health Specialist

Answer: Hello, Welcome to icliniq.com. At 26, especially if the pain has been persisting for a long while (5 years as you write) and affecting work and mobility indoors, it is a matter of concern. The only good thing that I gather from the notes is that you mention no weakness or numbness. Now coming ...  Read Full »

How to deal with depression when I do not feel to live?

Query: Hello doctor, I have depression, and it is getting worse. I do not want to live anymore. I just want to go to sleep and not wake up. I do not feel I will be a happy person ever. I can not live like this anymore. I am currently on Duloxetine medication.  Read Full »

Dr. Suresh Kumar G D

Child Health Specialist, Paediatrician, Psychiatrist

Answer: Hello, Welcome to icliniq.com. Your words are reflecting your distressed mental state, and it is obvious that you need more support to get over this difficult period. How long have your depression symptoms been getting worse? Is anything stressful happening recently? Do your family and friends know ...  Read Full »

Can Cymbalta be used for symptoms of OCD?

Query: Hi doctor, I am a 32 year old man. I have been experiencing panic disorder, OCD symptoms and excessive levels of anxiety. In the last few months, major changes in my life have happened. For instance; quitting my job and moving to another city triggered my anxiety symptoms. I usually feel drowned in ...  Read Full »

Dr. Abhijeet Deshmukh

Psychiatrist, Psychotherapist

Answer: Hi, Welcome to icliniq.com. Thank you for describing your query in detail. To start with, you might be absolutely right in saying that the current increase in your anxiety and associated feelings could be secondary to the change of place. Change of residence and workplace is always an anxiety-provok...  Read Full »

How to get rid of constant lower back and neck pain?

Query: Consistent lower back and neck pains. yes, I've been diagnosed with having a cervical disc herniation since 20 years and a lumbar disc herniation since 12 years. An L2 Nerve block procedure was performed in 11 years back. The last MRI I did was 3 years back.  Read Full »

Dr. Atul Prakash

Fitness Expert, Orthopaedician And Traumatologist, Physiotherapist, Spine Health Specialist

Answer: Hello Yes the MRI does talk about the disc bulges both in the neck and the back but it is now clear as to the degree of nerve root compromise as canal encroachment as this will determine the degree of symptoms and likelyhood of conservative management succeeding. I really need to see the MRI films ...  Read Full »

Can I use Paroxetine for bipolar II disorder, anxiety disorder, and agoraphobia?

Query: Hello, I'm looking and would like to discuss my treatment options for my conditions. I've bipolar disorder II, social and generalised anxiety disorders, panic attacks and agoraphobia due to it. In past, I used escitalopram, venlafaxine, fluoxetine, sertraline, lithium, depakote, quetiapine,...  Read Full »

Dr. Vishal Anilkumar Gandhi


Answer: thank you for taking help from psychiatrist. you should continue medications on which you are stable at present. 1)duloxetine may be good option for you. it does not increases blood pressure. 2)tablet escitalopram takes around 4 weeks for full effect after starting medications. 3) yup,prozac can dec...  Read Full »

Will switching to Wellbutrin from Cymbalta cause any adverse effects?

Query: Hi doctor, My current medications are 60 mg Cymbalta for depression and 300 mg Seroquel for the sleep disorder. I am in my 40s and I have had a few episodes of depression during my lifetime. I was lucky enough to be able to attend a psychiatrist in a country I lived in for a long time. It was a g...  Read Full »

Dr. Vishal Anilkumar Gandhi


Answer: Hi, Welcome to icliniq.com. Thank you for taking help from a psychiatrist. You can take Cymbalta and Seroquel. You are already on both medications, so you should continue both medications. If you fill depressed then take tablet Wellbutrin 150 mg once in the morning for a short period of time, th...  Read Full »

Is there any pharmacological substitute for Duloxetine?

Query: Hello doctor, My mother is 53 years old, nondiabetic. She is hypertensive (150-100) and having all over body pain, fatigue and morning stiffness. We consulted a neurologist and she was diagnosed with fibromyalgia. She was going about daily activities by using painkiller every day (Innova-MR, Diclo...  Read Full »

Dr. Aida Quka


Answer: Hello, Welcome to icliniq.com. Regarding your concern, I would explain that morning stiffness is not a typical sign of fibromyalgia, but it could indicate a rheumatological disorder. Coming to this point, considering her slightly elevated erythrosedimentation, I would recommend performing other...  Read Full »

Please suggest best treatment for fibromyalgia.

Query: Hello doctor, I was diagnosed with fibromyalgia a few years ago. Over the past three years, it has gotten much worse. I take Lyrica two times a day and Tramadol as needed for the pain. I still have a great deal of pain every day. The Lyrica makes me feel like I cannot think straight and the Tramado...  Read Full »

Dr. Anshul Varshney

Criticalcare Physician, Diabetologist, General Medicine Physician, Internal Medicine Physician, Medical Gastroenterologist, Nephrologist, Pulmonologist, Rheumatologist

Answer: Hi, Welcome to icliniq.com. Fibromyalgia is a very frustrating condition, but with the help of the patient, a doctor can treat it. I have treated my patients with all the drugs you have mentioned by managing the doses, but I always ask my patients to do meditation that would help the most in this ...  Read Full »

How to overcome the manic episodes caused by Cymbalta?

Query: Hello doctor, I recently was on Cymbalta minimum dose but did not feel better. I felt worse and was told to up the dose then I took 120 mg, still felt bad. So I abruptly stopped this and it triggered discontinue syndrome and hypermania. I have not felt the same since. I am not suffering so much now...  Read Full »

Dr. Aditya Gupta

Psychiatrist, Sexologist

Answer: Hello, Welcome to icliniq.com. Considering the history of mania (even if it is drug-induced), it is not advisable to start Effexor alone in my opinion. So, I would suggest you discuss with your treating psychiatrist regarding starting Seroquel regularly as it also acts on depressive symptoms, or...  Read Full »

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