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Should I switch my Methotrexate or add Prednisone for my RA?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I have been living with rheumatoid arthritis for many years and have been treated by several doctors. My most recent treatment included 15 mg of Methotrexate per week and daily Salazopyrin (Sulfasalazine), but I had to stop Salazopyrin as it affected my kidneys. I am currently experiencing a severe flare.

Should I increase my Methotrexate dose or take Prednisone along with it to manage the symptoms?

Please help.

Thank you.

Answered by Dr. Prakashkumar P Bhatt

Education:

MBBS

Professional Bio:

Dr. Prakashkumar P. Bhatt is a dedicated Neurologist committed to providing comprehensive care for patients with neurological conditions. He is skilled in diagnosing and managing a wide range of disorders, combining clinical expertise with a compassionate approach to treatment. Known for his clear communication and patient-centered care, Dr. Bhatt focuses on creating personalized treatment plans that support better health outcomes and improved quality of life.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I have read your query and can understand your concern.

It sounds like you have been managing rheumatoid arthritis for a long time, and going through a flare after so many years can be really frustrating. The pain and stiffness you are feeling now are most likely due to increased inflammation in your joints.

About Methotrexate:

You are already on 15 mg once a week, which is a moderate dose. Sometimes, doctors increase it to 20 to 25 mg during active flares, but this should only be done under your rheumatologist’s guidance. Before adjusting the dose, they will usually check your liver and kidney function to make sure it is safe. Try not to increase it on your own.

About Prednisone:

A short course of low-dose Prednisone (around 5 to 10 mg daily) can help calm things down when symptoms suddenly worsen. It can reduce swelling and pain while Methotrexate continues to work in the background. Still, it is important to taper it slowly and not stay on it for too long, since steroids can affect bones, blood sugar, and immunity.

Some helpful reminders:

  1. Keep taking Folic acid with Methotrexate, as it helps protect your liver and blood cells.

  2. Get regular blood tests for kidney, liver, and blood counts.

  3. If Methotrexate alone is not enough, your doctor might add another medication like a biologic (Adalimumab, Etanercept, or Tocilizumab), which can help control inflammation safely.

  4. Try gentle exercises, stretching, and warm compresses; they can make your joints feel a bit easier to move.

In short:

Do not adjust methotrexate on your own. Reach out to your rheumatologist soon. They might temporarily add Prednisone or adjust your treatment plan to help you get better control of your flare, while keeping your kidneys safe.

I hope this answers your query.

Please let me know if I can assist you further.

Thank you.

Medically reviewed by iCliniq medical review team
Published At January 9, 2026
Reviewed At January 9, 2026

Education:

MBBS

Professional Bio:

Dr. Prakashkumar P. Bhatt is a dedicated Neurologist committed to providing comprehensive care for patients with neurological conditions. He is skilled in diagnosing and managing a wide range of disorders, combining clinical expertise with a compassionate approach to treatment. Known for his clear communication and patient-centered care, Dr. Bhatt focuses on creating personalized treatment plans that support better health outcomes and improved quality of life.

This doctor is not available for online consultations on the platform anymore.

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Decision Helper
RA Flare Medication Adjustment Decision Helper

Facing an RA flare?

This tool helps you evaluate factors related to your rheumatoid arthritis medication, like Methotrexate and Prednisone, to prepare for a discussion with your doctor.

Medications should be taken after consulting a physician. The dosages will be prescribed by the physician. Do not alter, start, or stop medications without consulting a healthcare professional. Consult a qualified healthcare professional for personalized medical guidance.

Education:

MBBS

Professional Bio:

Dr. Prakashkumar P. Bhatt is a dedicated Neurologist committed to providing comprehensive care for patients with neurological conditions. He is skilled in diagnosing and managing a wide range of disorders, combining clinical expertise with a compassionate approach to treatment. Known for his clear communication and patient-centered care, Dr. Bhatt focuses on creating personalized treatment plans that support better health outcomes and improved quality of life.

This doctor is not available for online consultations on the platform anymore.

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