iCliniq Logo
HomeAnswersHIV/AIDS specialisthiv testing

What causes symptoms after HIV exposure despite taking PrEP?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I was exposed to HIV (human immunodeficiency virus) positive person as I was the anal receptive partner. In the first week of this month, and somewhere in the middle after this, I was exposed twice. I started feeling tired, had body aches and headaches after two days of exposure, then chills the next day, and felt febrile. I was taking daily PreP (pre-exposure prophylaxis) on all days. I have had several unprotected anal receptive sex in the past two weeks, all with escorts.

But this person was the only confirmed positive case. I had his results sent to me two days ago; the tests were performed last month, and he was positive for HIV and syphilis. He was newly infected and was not on any medications, and he may have a higher viral load. The sex was brutal with deep ejaculation. Please give your advice on this.

Thank you.

Hello,

Welcome to icliniq.com.

Thanks for writing in, and I understand your concern.

Suppose you have been initiated on pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) at least seven days before the risk exposure. In that case, the protection rates for receptive anal intercourse are high. These only protect against HIV, not against other sexually transmitted diseases (STDs).

So, there are possibilities of transmission of syphilis. It would always be better to avoid the risk exposure. At least you can use condoms to prevent other STDs. Anyway, they will follow the HIV and STDs testing protocol in your setting. Usually, you will be screened for HIV and STDs every three months.

I hope this helped.

Regards.

Patient's Query

Hello doctor,

Thank you for your response.

Is it likely that I had contracted HIV from this person on exposure in the middle week of this month? Because my symptoms started the very next day. I have heard that if the symptoms appear, it is after two weeks. Also, I have been on PreP for two years. I was positive for syphilis for at least six months and was treated, and antibody tests were checked two months ago.

What else could it be if it is not HIV? I had body aches, chills, and felt feverish. I developed herpes labialis five days after exposure. I have had herpes every six months. My HIV test was negative one month ago. Would you please give me your opinion on this?

Regards.

Hello,

Welcome back to icliniq.com.

Yes, even herpes can manifest with fever and body aches. Any infection, viral infection, or HIV can manifest with such symptoms. These are non-specific symptoms.

Regards.

Patient's Query

Hello doctor,

Thank you for your response.

What about night sweats? I started sweating at night today, and it is only 8 degrees Celsius in my room. I am also sweating under my ankles.

Please help.

Regards.

Hello,

Welcome back to icliniq.com.

In my opinion, these too can be non-specific or due to any infection.

Thank you.

Medically reviewed byiCliniq medical review team

Published At January 29, 2022
Reviewed AtDecember 19, 2025

Same symptoms don't mean you have the same problem. Consult a doctor now!

Listen to related tracks in our music library

Read answers about:

syphilishiv testing

Ask your health query to a doctor online

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.