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What to do if Metformin and Glibenclamide lose their effect?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

My mother has diabetics type 2. Currently, she is using Metformin 500 mg two times a day with Glibenclamide. The problem is it is not dropping as before. Can you please help with other medications or tablets?

Please help.

Thank you.

Hi,

Welcome to icliniq.com.

I completely understand your concerns.

Your mother has Type 2 diabetes mellitus, which is a chronic metabolic disorder characterized by high blood glucose levels due to insulin resistance and a relative lack of insulin production. This condition is often associated with factors such as genetics, age, obesity, physical inactivity, and poor dietary habits.

Your mother needs some different medications, Glimepiride 3 mg before breakfast, Sitagliptin Metformin combination of 50/850 twice daily after meals. Decrease fats in her diet, avoid fast food. Increase physical activity if possible. Sugary things should be avoided altogether. Report me after one week.

I hope this helps.

Kindly revert if there is any query.

Thank you.

Medically reviewed byDr. Nithila. A
Published At August 6, 2019
Reviewed AtOctober 15, 2025

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