I have UC and want to get pregnant. How should I manage it?

Hello,

Welcome to icliniq.com.

I read your query, and I can understand your concern.

So, with your symptoms of increased stool frequency, mucus, and elevated fecal calprotectin and CRP (C-reactive protein), it is quite likely that you are experiencing a mild to moderate flare of ulcerative colitis or a partial response to your current treatment regimen.

Medications like Mesalamine and Azathioprine are commonly used as maintenance therapies, and both are generally considered safe in pregnancy, but disease control before conception is crucial, as active disease during pregnancy increases risks for both mother and baby.

Escalation to biologic therapy, such as anti-TNF (tumor necrosis factor-alpha inhibitors) agents like Infliximab or Adalimumab, may be considered if your current treatment is not achieving remission. These biologics are also regarded as relatively safe in pregnancy, particularly if disease activity warrants their use.

But before making any further changes, I suggest you do stool cultures to rule out infections and possibly a flexible sigmoidoscopy to assess mucosal healing. Achieving and maintaining remission before conception significantly improves outcomes, so it is important to act early for a safe and healthy pregnancy with well-controlled disease.

I hope this helps.

Feel free to reach out at any time. I am always here to help.