I am on week six of my estrogen therapy and getting a lot of creamy white discharge. Why?

Q. What could cause creamy white discharge in a patient on week six of estrogen therapy?

Answered by
Dr. Uzma Arqam
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Apr 20, 2023

Hello doctor,

I am not sure if you will be able to give any advice, but 14 years ago, I had leukaemia, and my treatment involved chemo and total body radiation. My periods stopped straight away, and I went into early menopause at 20. I went to a fertility clinic about 10 years ago as I was interested in IVF with egg donation, but they said that the radiation would have caused too much damage to the uterus and it would not work, but they never did any tests. I asked for tests a few months ago, and there was no noticeable damage. The scan just showed I had a thin uterus lining, so the doctor has put me on Estrogen three times a day for eight weeks to see if it will thicken and see if egg donation would be possible. I am now on week 6 and getting a lot of discharge, mostly creamy and stretchy. Does this mean my lining is getting thicker? And do you think that egg donation would work? Please suggest.

Thank you.



Welcome to icliniq.com.

I have read your query and understand your concern.

Firstly thank God that after getting all the hard times now, you are healthy, and I hope you will get what you want. Estrogen is given to you to stimulate and prepare the reproductive system for the IVF (In vitro fertilization) procedure. As per your description, your body is gradually getting better from the previous condition.

I feel that the discharge might be due to some local infection or accumulated discharge that is coming out, or local chemo-treated tissues trying to respond to Estrogen. If you feel irritation or pain, you can have a high vaginal Swab to test in the lab to have treatment if any particular organism is causing it. Sit in mildly warm water to get relief in case of irritation. Do follow strict local hygiene. Wear soft, comfortable cotton undergarments. Use Condoms to avoid transmission of sexually transmitted infections.

I hope this helps.

Good luck.


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