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Rabies Vaccine - Types, Indication, Contraindications, and Side Effects

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Rabies is a vaccine-preventable, zoonotic viral disease of mammals usually transmitted through the bite of an infected animal.

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Dr. Pandian. P

Published At November 2, 2022
Reviewed AtNovember 2, 2022

Introduction:

Rabies is one of the most deadly infectious diseases. The virus is transmitted through exposure to saliva from an infected animal bite, such as bats, cats, dogs, and raccoons. It is most commonly transmitted through dog bites. However, it can also be transmitted from inhalation of the aerosolized rabies virus, through organ or tissue transplantation, or if the broken skin or mucous membrane comes in contact with any infected body fluid.

How Is the Rabies Vaccine Given?

The rabies vaccine is used in two ways. First, it can be given to the person exposed to the animal via a bite, lick, or scratch or to the person who is thought to have rabies. The rabies vaccine is given as an intramuscular injection. For adults, the vaccination should always be given intramuscularly in the deltoid muscle (arm), and for children, the vaccination should be given on the anterolateral aspect of the thigh.

The rabies vaccination should not be given in the gluteal area. Three doses of vaccines are given pre-exposure. Dose one is appropriate, dose two is given seven days after dose one, and dose three is given 21 or 28 days after dose one. Even if the person is vaccinated, they may need the booster dose if they are traveling to a high-risk area or are at risk because of the job.

One booster dose is considered for travelers who were vaccinated a year ago and are now traveling to high-risk areas. It takes four weeks to complete the vaccination course, so one needs to start the vaccination one month before planning to travel.

Who Discovered Rabies Vaccine?

Louis Pasteur discovered the rabies vaccine on July 6, 1885. The rabies vaccine is given to people who are at high risk of being exposed so that it can prevent them. It can also be given to the exposed person to prevent disease. The rabies vaccine is made from the killed rabies virus. The rabies vaccine is only to be given under a doctor's or other healthcare provider's supervision.

Who Should Get the Rabies Vaccine and When?

The rabies vaccine is indicated in the following people:

  • The people at high risk of exposure to rabies include rabies lab workers. These people handle animals, veterinarians, spelunkers, and rabies biologics production workers.

  • Anyone who is bitten by an animal or who is exposed to rabies should visit the doctor immediately.

  • The lab workers, as well as the others, are repeatedly exposed to the rabies virus. For such people, periodic testing for immunity is recommended, and the booster dose is given as needed.

  • The people who are always in contact with rabid animals or rabies virus.

  • International travelers are likely to come in contact with animals or travel to high-risk areas where rabies is common.

  • If the person is exposed to the rabies virus and is never vaccinated against rabies, they must get four doses of the rabies vaccine. Dose one should be given immediately, and the additional doses on the third, seventh, and 14th days along with another shot called rabies immune globulin, at the same time as the first dose.

  • The previously vaccinated person should get two doses of the rabies vaccine.

  • The healthcare provider will perform a routine blood test before or after the rabies vaccination to determine your immunity against the rabies vaccine.

  • People who are suffering from minor illnesses such as colds can be vaccinated.

  • People who are severely ill should wait until they recover before getting vaccinated.

What Are the Symptoms of the Rabies Virus?

Initially, there might not be any symptoms. But a few weeks or years after the bite, rabies can cause pain, mental confusion, headache, fever, abnormal behavior, hydrophobia, fatigue, insomnia, and irritability. Seizures, paralysis, and hallucinations can follow these symptoms. People get rabies if infected by the virus or come in contact with the saliva, bite or scratch and do not receive appropriate medical care, including the rabies vaccine.

What Are the Reactions to the Rabies Vaccine?

One should consult your doctor immediately if any of the following side effects occur:

  • Chills.

  • Dizziness.

  • Muscle or joint pain.

  • Abdominal pain.

  • Nausea.

  • Headache.

  • A general feeling of discomfort or illness.

  • Itching or pain at the injection site.

  • Hives.

  • Vision changes and tinnitus.

What if There Is a Moderate or Severe Reaction?

There can be severe allergic reactions or a high fever. A severe allergic reaction could occur within a few minutes to an hour after the shot.

  • The signs of a severe allergic reaction include throat swelling, difficulty breathing, hives, paleness, weakness, tachycardia, dizziness, hives, and wheezing.

  • Reach out to the doctor immediately.

  • Explain in detail the allergic reaction.

How Can You Prevent Rabies?

There are some tips to prevent rabies:

  • Try to maintain control of your pets by keeping them indoors and under supervision.

  • Visit your veterinarian and your pet regularly and keep the vaccinations up-to-date with your pets.

  • Take help from animal control to remove stray animals in your neighborhood, as they may be unvaccinated.

When Should You Consult Your Doctor?

There are a few conditions where one needs to consult the doctor, and they are

  • Talk to your doctor if you previously had a life-threatening allergic reaction to a dose of the rabies vaccine or any components of the vaccine.

  • Talk to your doctor if you have any severe allergies.

  • If you are immunocompromised, have a disease like human immunodeficiency syndrome (HIV)/AIDS, or are undergoing treatment with drugs that can affect the immune system.

  • If undergoing cancer treatment or radiation therapy.

  • If you are on chloroquine or any drug that is related to chloroquine.

  • If you have been previously vaccinated.

Conclusion:

Rabies is almost fatal. Most cases include bites from unvaccinated dogs, but the rabies vaccine can prevent rabies.

Frequently Asked Questions

1.

When Should Rabies Vaccinations Be Administered?

To previously unvaccinated individuals, a regimen of four 1-mL doses of the HDCV (human diploid cell vaccine) or PCEC (purified chick embryo cell vaccine) vaccination should be intramuscularly delivered. The four-dose course's initial dose needs to be given as soon as feasible following exposure. On days 3, 7, and fourteen following the initial immunization, further doses should be given.

2.

Can I Get a Rabies Shot Three Days After a Dog Bite?

Rabies is nearly always fatal if untreated. A bite or exposure of broken skin to the saliva of an infected animal can cause people to contract an acute viral infection known as rabies. In most cases, early immunization can prevent the sickness (ideally within 24 hours, but definitely within 72 hours).

3.

How Many Rabies Vaccinations Are Required?

- If individuals have never received a rabies vaccination, they will require four doses over the course of two weeks. (on days zero, three, seven, and 14). On the day they take the first dose of the rabies vaccination, or shortly after, they should also receive a different drug called rabies immunoglobulin.
- If they have previously received rabies immunization, they usually only require two doses of the vaccine following exposure.

4.

Is There a 3 Or 4 Dose Rabies Vaccine?

Without prior immunization, persons who have been exposed to rabies are given the vaccine soon after exposure in order to prevent the progressing, always fatal disease rabies. In these cases, four shots are administered to adults in the shoulder muscle or four shots to children in the thigh.

5.

Can I Get a Rabies Shot After a Day of Being Bitten by a Dog?

Get medical attention as soon as a dog, cat, bat, or other mammal that one might suspect of having rabies bites someone. Within the first 24 hours following exposure, the vaccine's first dose should be given.

6.

How Long After a Rabies Bite May Be a Vaccine Administered?

Post-exposure prophylaxis is to be started as soon as feasible after the exposure if exposure to rabies is thought to be very likely. A maximum waiting period of 48 hours is advised if the start of post-exposure prophylaxis is postponed until test results from the concerned animal are available.

7.

Is It Too Late to Get a Rabies Shot After 7 Days?

Regarding the administration of PEP (post-exposure prophylaxis) following exposure, there is no time restriction. Initiating PEP is still appropriate in this situation. Regardless of how long it has been after the exposure, giving a person four doses of the rabies vaccination and the human rabies immune globulin (HRIG) is advised.

8.

How Should a Small Dog Bite Be Handled?

If the bleeding is not severe, clean the wound with soap and water and place it under running water for a while. Dry the wound, apply an antibiotic cream, and then wrap it in sterile gauze or a fresh piece of clothing. Even if the area is small, if the bite or scratch tore or penetrated the skin, call the doctor.

9.

Is It Okay if a Dog That Has Received Vaccinations Bites You?

If the dog has had the necessary rabies vaccination and if laboratory results support the vaccine's efficacy, vaccination is not required. If not, a suitable post-exposure prophylaxis (PEP) should be administered.

10.

Can I Bathe After a Dog Bite?

Before taking a shower, wrap the bandage in plastic if the physician has stitched up the wound. After 24 to 48 hours, the physician could suggest patients take off the bandage and carefully wash the site to get rid of the crust. Avoid scrubbing or soaking the wound.

11.

Are Two Rabies Shots Enough?

The three-dose rabies vaccine schedule has been replaced with a two-dose vaccination schedule that will protect against rabies for at least three years, according to updated guidelines from the Centers for Disease Control and Prevention for rabies pre-exposure prophylaxis for humans.

12.

Are Two Rabies Shots Enough?

The three-dose rabies vaccine schedule has been replaced with a two-dose vaccination schedule that will protect against rabies for at least three years, according to updated guidelines from the Centers for Disease Control and Prevention for rabies pre-exposure prophylaxis for humans.

13.

When Do the Signs of Rabies Appear?

The first signs of rabies might show up anywhere between a few days and more than a year after the attack. Around the bite region, there is first a tingling, prickling, or itching sensation. Additionally, a person may experience flu-like symptoms such as fever, headache, muscular aches, appetite loss, nausea, and fatigue.

14.

Does Rabies Result From Every Dog Bite?

Domestic dogs are to blame for human rabies virus transmission in up to 99 % of instances. Rabies, however, can strike both domestic and wild animals. It is typically transmitted to people and animals through bites, scratches, or direct contact with mucosa (such as the eyes, mouth, or open wounds) via saliva.

15.

Can Alcohol Kill Rabies?

Rarely does intact skin contact with infectious tissue or fluids pose a risk for virus transmission. No contaminated items or materials, such as clothing or bedding, can spread rabies. Because the rabies virus is delicate, desiccation (drying out), ultraviolet radiation, and ordinary disinfectants can all kill it.

16.

Do All Dogs Have Rabies?

Not all dogs carry rabies, despite what many people think. However, if they are bitten by an animal that is infected, they could contract the rabies virus.

17.

Who Is Most Susceptible to Rabies?

The risk of rabies is frequently highest among children. They are more prone to be bitten by dogs and to suffer serious injuries from several bites in high-risk areas of the body. When exposures are severe, it can be more challenging to avoid rabies unless prompt access to quality medical care is provided.
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Dr. Pandian. P
Dr. Pandian. P

General Surgery

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