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Preventive Medications for Migraine

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Some drugs stop migraine symptoms from occurring. Continue reading the article below to learn more about such a kind of treatment.

Written byDr. Divakara. P

Medically reviewed byiCliniq medical review team

Published At June 18, 2015
Reviewed AtMay 8, 2025
Preventive Medications for Migraine

Introduction

Migraines are awful headaches. Visions are hot with flashing lights, and sounds are deafening with noise. Even walking can make the symptoms worse. But you might not know that you can stop the onset. Well, some medications will stop the headaches from occurring if taken when the onset begins. Let us explore this further.

Knowing Migraines and Their Effects

Individuals miss work, play, or school due to such headaches as migraines. Others suffer intense loss of sleep or see flashing lights before a migraine. A migraine may be caused by anything ranging from tension to food intolerance and loss of sleep.

Preventive Care and Its Importance

Preventive medication is significant; it keeps the headache away before it happens. Your doctor may recommend a medication (preventive medication) with constant modifications to eliminate the headache. They will not cure headaches, but will prevent their development.

Which Medications Prevent Migraine?

Most of the drugs used for migraine are preventive. There is a need to use medication constantly. Some of them are:

  • Anticonvulsants- They dampen or suppress seizures. Anticonvulsants seem to be useful when it comes to migraine prevention. How this benefit is achieved can be attributed to the impact these drugs have on the central nervous system; their effects are bound to be relevant to the pathophysiology of migraine. To prevent headaches, doctors can prescribe Topiramate or valproic acid. Anti-seizure drugs can lead to drowsiness. You also might have difficulty concentrating.

  • Antidepressants- Antidepressants are also very much utilized to prevent migraines. This is exemplified nicely by using Amitriptyline for anticipatory purposes. In case a patient might not be able to handle Amitriptyline (an FDA-accredited antidepressant for adults dealing with depression), Nortriptyline (a medication intended to reduce the pain from the nerves) could be used. Co-morbid sleep disturbances or insomnia individuals could benefit from the sedation of Nortriptyline (TCAs, tricyclic antidepressants).

  • Depression and migraine patients would also benefit most from SNRIs (serotonin-norepinephrine reuptake inhibitors), Venlafaxine, and Duloxetine, which also carry supporting evidence. SSRIs (selective serotonin reuptake inhibitors), such as Fluoxetine, are ineffective in the majority of patients. Antidepressants have equally severe side effects. Special counseling regarding the risk of withdrawal symptoms when stopping SNRI should be given to the patients. Antidepressants are a good choice for migraine prevention. The efficacy and tolerability of SNRIs as migraine preventives need to be investigated further.

  • Beta-blockers- These slow your heart rate and dilate your blood vessels. They are usually prescribed for high blood pressure. Your doctor can prescribe Timolol, Propranolol, Nadalol, Metoprolol, or Atenolol for migraines. Sexual dysfunction and depression are possible side effects.

  • Calcium Channel Blockers- By inhibiting the entry of calcium ions into cells, calcium channel blockers can induce vasodilatation of blood vessels and, in doing so, reduce the frequency and severity of migrainous attacks. They stabilize blood vessel walls and inhibit spasms, particularly in migraines with aura. Some examples are Verapamil and Diltiazem, which are used in the management of cardiac disease and to reduce blood vessel constriction.

  • Calcitonin Gene-Related Peptide (CGRP) Inhibitors- Calcitonin gene-related peptide (CGRP) inhibitors inhibit the activity of CGRP, a small molecule present everywhere on sensory neurons that supply the head and neck. CGRP levels rise during migraines and play a role in pain transmission. It can even be a causative factor in the occurrence of migraine attacks. CGRP inhibitors are used to treat migraines. Certain ones are monoclonal antibodies (mAbs) and small-molecule antagonists (Gepants).

Lifestyle Changes and Migraine Prevention

Daily habits give one such a great grip on breaking migraine. These are easy changes; people feel a lot better about it. Some of them are:

Dietary Factors

Some foods trigger migraines and need to be eliminated entirely. Chocolate, caffeine, and packaged foods (if used in excess) will be offenders. If one eats only fresh, whole food and plenty of water, the result would be nothing short of a miracle (not just for migraines).

Exercise (How Much and When?)

Exercise can even ward off migraines and headaches. Walking and stretching are also okay. Excessive exercise, particularly intense exercise, will cause headaches, so be careful about that. Consistent, moderate aerobic exercise can cut back, lessen the frequency, and reduce migraines in many individuals. It also serves to manage stress, another trigger.

Stress Management Techniques

Migraines are typically caused by stress. Two very soothing, stress-reducing activities are slow breathing and soothing music. Breaks, family time with your pets, or even some plain exercises can be relaxing, too.

Sleep Hygiene Importance

Sleep will eliminate migraines in their tracks at any moment. Go to bed at the same hour every evening and have no screens for at least an hour.

Other Alternative and Complementary Therapies Modalities: What Are They?

The Use of Acupuncture

Acupuncture employs tiny needles in different parts of the body to alleviate pain and ease headaches.

Other Herbs

Certain herbs can be used for migraines. Certain plants are useful when consumed with drug prescriptions. But you must see a doctor first before you consume it.

  • Butterbur

Butterbur is a vegetable that is normally eaten to prevent headaches. However, it cannot be eaten raw because it is toxic.

  • Feverfew

Feverfew is an annual herb with leaves. Feverfew is used to cure migraines.

Cognitive Behavioral Therapy and Biofeedback

Biofeedback controls your heartbeat and then your muscles. Cognitive behavioral therapy (CBT) helps you resist stress and negative thoughts, which tend to increase migraines.

Pursuing the Guidance of a Medical Doctor: Why Is It Necessary?

It requires working with a doctor to get it done correctly. It is best to work with doctors to treat your migraines, and they can assist in dictating the right course of action to avoid them.

The Need for Personalized Treatment Plans

Each person is unique. Something that is beneficial for one may not be so for another. A doctor can prescribe medication that is best for each person.

Medication Monitoring and Adjustment

There are occasions when medication has to be adjusted. If the medicine does not work anymore or has horrid side effects, see a doctor. Keep a migraine diary to determine what can trigger migraines.

Conclusion

Preventing migraines will pay you back in the form of quality of life and blissfulness. A healthy diet, stress balance, good sleep, and proper treatment will decrease its frequency. Your physician can help you find the best regimen so that you can spend headache-free, blissful days.

A Note From iCliniq

Migraines are disabling but can be controlled by preventive medication. Some herbs also prevent migraines. The medicine has to be taken under the supervision of doctors. iCliniq experts can provide relief and prevention of migraines with their extensive experience and knowledge!

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Frequently Asked Questions

Some simple ways to prevent migraine attacks are:  
- Avoid eating foods that trigger a migraine such as chocolate, cheese, alcohol, dairy products, processed foods, and cold items.  
- Do not skip meals.  
- Avoid smoking.  
- Maintain a normal sleep pattern.  
- Manage stress.
The food items that do not trigger migraines are:
- Vegetables like sweet potatoes, spinach, and carrots.
- Brown rice.
- Fruits.
- Natural sweeteners like maple syrup.
Most people feel better after drinking a strong cup of coffee when they have a headache. This is because of caffeine present in the coffee. But people who get migraines should stay clear of coffee or other caffeinated beverages. This is because consuming two to three cups of coffee every day might develop a dependency, which increases the frequency of migraine attacks.
Apart from taking your medicines, you can try the following ways to get rid of a migraine:
- Apply a cold pack or hot compress.
- Try massaging your head and neck.
- Avoid sitting in rooms that are brightly lit.
- Stretch and perform yoga and meditation.
Don’ts:
- Skip meals.
- Exercise a lot and tire yourself.
- Go out in the hot climate.
- Spend too much time looking at digital screens.
- Grind your teeth together.
- Drink too much alcohol.
- Smoke.
Do’s:
- Stick to a sleep routine.
- Limit the intake of coffee.
- Keep yourself hydrated.
- Keep a treatment plan ready for pain during periods or menopause.
- Manage stress.
- Keep your surroundings clean to prevent bad odor.
By identifying and avoiding the following triggers, you can decrease the frequency of migraine attacks:
- Bright light.
- Loud noise.
- Food like wine, chocolate, and cheese.
- Changes in sleep patterns.
- Stress.
- Too much physical activity.
- Hormonal changes.
A migraine usually causes severe pulsating or throbbing kind of pain on one side of the head (unilateral headache). Symptoms like nausea, vomiting, and sensitivity to light and sound are usually accompanied by a migraine attack.
A typical migraine attack can last from anywhere between 4 and 72 hours. If you have a severe headache even after 3 days, consult a doctor immediately.
The exact cause and mechanism of migraine are still not known, but it is believed to be caused by abnormal brain activity. This change in brain activity affects the blood vessels and the way nerves communicate in the brain.
Migraine is usually diagnosed based on the symptoms and after all other possible causes are ruled out with the help of an MRI or CT scan.

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