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I am fatigued with severe bone pain, and have abnormal smear findings. Is my cancer recurring?

Query: Hello doctor,I have a history of breast cancer for which the treatment got completed around two years back.Following are the current findings of my blood smear:Anisocytosis: +1,Poikilocytosis: +1,Polychromasia: +1,Ovalocytes: +1,And a few atypical lymphocytes.I am feeling very weak with severe bone ...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello,Welcome to is my opinion of your findings:Anisocytosis means variations in the size of red blood cells and poikilocytosis is variations in the shape of red blood cells. These two findings together with polychromasia could be because of hemolytic anemia. However, anemia is...  Read Full »

Is anisopoikilocytosis dangerous?

Query: Hello doctor, I am a 53 year old woman diagnosed with polycythemia vera (PV) three years ago. I am being treated with phlebotomy. I have fatigue at times, as well as some thinking impairment at times. Over time I have developed various anomalies in my blood test results, which my doctor explained as...  Read Full »

Dr. Prakash H. Muddegowda

Answer: Hi, Welcome to Based on your query regarding polycythemia, my opinion is as follows: Due to nutritional deficiencies, secondary to excessive RBC (red blood cell) production and also mild dyserythropoiesis (defective development of red blood cells), you can find microcytic hypochromic...  Read Full »

What does anisopoikilocytosis mean in my CBC?

Query: Hello doctor, This is my CBC report and everything is normal except RBC. In it, RBC shows anisopoikilocytosis predominantly microcytic hypochromic cells along with normocytic hypochromic cells and few targets cells. WBC is within normal limits. Platelets: adequate. (MCV) mean corpuscular volume72.0 ...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to Your report is suggestive of microcytic hypochromic anemia. Do not worry about that. It is a treatable condition. With the recovery of hemoglobin level by tablet, your PS (peripheral smear) will be reverted to normal. It is not an alarming condition. But I suggest th...  Read Full »

What is the treatment for high platelets count with mild anisopoikilocytosis?

Query: Hello doctor, My wife is having high platelets count, diagnosed with mild anisopoikilocytosis, predominantly normocytic with ovalocytes (RBC), WBC mild leukocytosis is present, platelets: appear increased in the smear.  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to The increased platelet count in your wife case seems to be due to reactive thrombocytosis. The iron deficiency anemia can lead to reactive thrombocytosis and so platelet count can be high. You need to treat her anemia with Ferrous Ascorbate tablet like medication for a...  Read Full »

My blood smear shows mild anisopoikilocytosis. Should I be concerned?

Query: Hello doctor, I am 39 years old. I got a master health checkup done last week. In the blood report, RBC smear shows mild anisopoikilocytosis with normochromic red cells mixed with microcytic, hypochromic red cells, and no hemoparasites. I am attaching my test report. What is the treatment for this?  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to I have gone through your test report (attachment removed to protect patient identity). Your peripheral smear showing mild microcytic RBC (red blood cells) and MCV (mean corpuscular value) are slightly low, but I do not think it needs any further workup as all other smear ...  Read Full »

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