Q. Can HLA B27 positve male with ankylosing spondylitis affect his children?

Answered by
Dr. Ashaq Hussain Parrey
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Feb 19, 2018 and last reviewed on: Oct 31, 2022

Hello doctor,

I am 26 years, and I had a hip resurfacing surgery eight years back. I am an HLA B27 positive, even my father is also positive. I have had joint pain for the last fourteen years. Now, I wish to know that if I marry and have children will this pass on to them? What measures should I take to ensure it does not pass on to the next generation? I am at crossroads, I need to take a decision based on the reply. Please give me the solution.



Welcome to

About 80 % of people with ankylosing spondylitis have HLA B27 positive, and only 1 to 4 % of people with positive HLA B27 develop ankylosing spondylitis. That means out of 100 people with positive HLA B27, only one to four can develop ankylosing spondylitis, and 96 to 99 are normal.

The chances of your children having positive HLA B27 is about 10 %. Now I do not think you should worry about your kids having ankylosing spondylitis or HLA B27.

Hi doctor,

Thank you for the reply.

I have been diagnosed with HLA B27 and ankylosing spondylitis. Even my father also has the same condition. And that 10 % is the additional risk compared to normal parents right?



Welcome back to

Yes, the chances of your kids having ankylosing spondylitis are 10 % each.

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